4748-81-6

Upstream product

• 622-96-8 4-methylethylbenzene 
• 62559-41-5 4-ethyl-3-nitrotoluene 
• 74-84-0 ethane 
• 108-44-1 1-amino-3-methylbenzene 
• 7647-01-0 hydrogenchloride 
• 1467-05-6 4-ethylbenzylchloride 
• 4748-78-1 4-ethylbenzylaldehyde 
• 143879-61-2 5-methyl-2-vinylaniline 
• 53078-85-6 2-bromo-5-methylaniline 
• 4748-80-5 4-ethyl-3-nitro-benzaldehyde 

Downstream Products

• 4748-82-7 2’-ethyl-5’-methylacetanilide 
• 854633-32-2 5-ethyl-2-methyl-1,3-dinitro-benzene 
• 854624-41-2 6-ethyl-3-methyl-2,4-dinitro-aniline 
• 858006-14-1 1-ethyl-4-methyl-2,3,5-trinitro-benzene 
• 683239-36-3 acetic acid-(6-ethyl-3-methyl-2,4-dinitro-anilide) 

Relevant academic research and scientific papers

THIAZOLE DERIVATIVES USEFUL AS MUTANT IDH1 INHIBITORS FOR TREATING CANCER

A compound of Formula II or a pharmaceutically acceptable salt thereof, wherein CyN is a cyclic amine group bound via a nitrogen atom; X is C or N; R1 and R2 are each independently a halogen, CN, CF3, CHF2, CH2F, a C1-C10alkyl group, a C1-C10alkoxy group, a di(C1-C5alkyl)amino; m and n are each independently 1, 2, or 3, and represents either a single bond or a double bond, wherein the racemic mixture of 3-(4-(4-chlorophenyl)thiazol-2-yl)-1-(2-ethyl-5-methoxyphenyl)-6-(2-methylprop-1-en-1-yl)-5-(piperazine-1-carbonyl)pyridin-2(1H)-one atropisomers is excluded.

MOLECULES HAVING CERTAIN PESTICIDAL UTILITIES, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES RELATED THERETO

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such molecules and intermediates used in such processes, compositions containing such molecules,

MUTANT IDH1 INHIBITORS USEFUL FOR TREATING CANCER

Compounds of Formula I and Formula II and the pharmaceutically acceptable salts thereof are disclosed The variables A, B, Y, Z, X1, X2, R1-4 and R13-18 are disclosed herein. The compounds are useful for treating cancer disorders, especially those involving mutant IDH1 enzymes. Pharmaceutical compositions containing compounds of Formula I or Formula II and methods of treatment comprising administering compounds of Formula I and Formula II are also disclosed.

MOLECULES HAVING CERTAIN PESTICIDAL UTILITIES, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES RELATED THERETO

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such molecules and intermediates used in such processes, compositions containing such molecules,

Intramolecular Selectivity of the Alkylation of Substituted Anilines by Gaseous Cations

The intramolecular selectivity of the electrophilic reactions of Et(1+), i-Pr(1+), and Me2F(1+) cations with substituted anilines, including m-toluidine, m-anisidine, and m- and p-fluoroaniline, has been investigated in the dilute gas state at pressures ranging from 100 to 720 torr by a radiolytic technique, complemented by chemical ionization mass spectrometry.The results indicate an appreciable kinetic bias for the nitrogen atom, leading to predominant N-methylation by Me2F(1+).The reactivity of the carbenium ions is complicated by the simultaneous occurrence of proton transfer, in particular to the NH2 group, which increases the relative extent of ring alkylation.The positional selectivity is characterized, aside from the usual orienting effects of the substituents, by the enchanced reactivity of the ring positions ortho to an n-type substituent, irrespective of its activating or deactivating properties.The effect is traced to the preliminary formation of an electrostatic adduct between the aniline and the gaseous electrophile.

Reactive yellow dye having both monochlorotriazinyl and vinylsulfone type reactive groups

The compounds represented, in the form of free acid, by the following general formula (I): STR1 (wherein A is STR2 (wherein R3 and R4 are each hydrogen or a methyl, ethyl, methoxy, ethoxy, acetylamino, propionylamino, benzoylamino or ureido group, and R5 and R6 are each hydrogen or a methyl or methoxy group), R1 and R2 are each hydrogen or a methyl, ethyl or sulfomethyl group, X1 and X2 are each hydrogen, chlorine or a methyl, methoxy, carboxyl or sulfonic acid group, m is a number of 0, 1 or 2, and n is a number of 1 or 2, provided that the sum of m and n is 1, 2 or 3). These compounds are capable of dyeing cellulose fibers in yellow with excellent color fastness to hypochlorite, light, perspiration and sunlight and high acid stability.