62576-11-8

Upstream product

• 826-83-5 4-methyl-5-phenyl-1H-imidazole 
• 333-27-7 methyl trifluoromethanesulfonate 
• 119-51-7 1-phenyl-1,2-propanedione 2-oxime 
• 1127563-14-7 1,4-dimethyl-5-phenyl-1H-imidazole 3-oxide 

Relevant academic research and scientific papers

Synthesis of optically active polyheterocycles containing pyrrolidine, imidazole, and 1,2,3-triazole rings

Optically active polyheterocycles containing pyrrolidine, imidazole, and 1,2,3-triazole units were obtained via a multistep synthesis with the [3+2] cycloaddition of Boc-protected (S)-(pyrrolidin-2-yl)methyl azide with 2-ethynylimidazoles in the presence of CuI (CuAAC reaction) as the key step. Typical for terminal alkynes, the reactions occurred regioselectively and 1,4-disubstituted 1,2,3-triazoles were formed exclusively. The deprotection of the pyrrolidine N-atom was performed by treatment with TFA under standard conditions.

Development of a regioselective N-methylation of (benz)imidazoles providing the more sterically hindered isomer

An efficient and highly regioselective N-methylation of (NH)-(benz)imidazoles furnishing the sterically more hindered, less stable, and usually minor regioisomer has been developed. The methodology involves very mild reaction conditions and tolerates a wide range of functional groups.