62584-59-2

Upstream product

• 105-07-7 4-cyanobenzaldehyde 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 51410-44-7 1-(4-methoxylphenyl)-2-propen-1-ol 
• 126747-14-6 4-cyanophenylboronic acid 
• 623-00-7 4-bromobenzenecarbonitrile 
• 19115-30-1 1-(4-methoxyphenyl)-2-propyn-1-ol 

Downstream Products

• 74261-28-2 4-(2-(4-methoxyphenyl)cyclopropyl)benzonitrile 
• 62584-73-0 4-(3-(4-methoxyphenyl)-3-oxopropyl)benzonitrile 
• 1266096-19-8 (R)-tert-butyl 2-oxo-5-((S)-1-(4-cyanophenyl)-3-oxo-3-(4-methoxyphenyl)propyl)-2,5-dihydro-1H-pyrrole-1-carboxylate 
• 1431881-36-5 ethyl 2-(4-cyanophenyl)-4-(2-methoxyphenyl)-2,3-dihydro-thieno[2',3':5,6]benzo[1,2-b][1,4]thiazepine-9-carboxylate 
• 1550138-71-0 C₃₆H₂₄BF₂N₅O₂ 
• 1550059-92-1 C₁₈H₁₆N₂O₄ 
• 1292816-32-0 4-(5-(4-methoxyphenyl)-2-phenylfuran-3-yl)benzonitrile 

Relevant academic research and scientific papers

Photoredox-Catalyzed Cyclopropanation of Michael Acceptors

A new protocol for the catalytic cyclopropanation of α,β-unsaturated carbonyl compounds with diiodomethane by means of photoredox catalysis has been successfully developed. The transformation is characterized by its mild conditions, functional-group compatibility, and excellent selectivity profile.

Unexpected solvent/substitution-dependent inversion of the enantioselectivity in Michael addition reaction using chiral phase transfer catalysts

New cinchonium salts bearing 5,5′-bis(methyl)-2,2′-bipyridine 1 group show solvent/substitution-dependent reversal of enantioselectivity. When used as chiral phase transfer catalyst in the asymmetric Michael addition of chalcones with diethylmalonate within two hours these catalysts result in high chemical yield (up to 98%) and enantiomeric excess (up to 99%) under lower concentrations of base and cold conditions.

Oxygen as single oxidant for two steps: Base-free one-pot Pd(ii)-catalyzed alcohol oxidation & arylation to halogen-intact β-aryl α,β-enones

Using oxygen as the sole oxidant for two steps, we developed a new method to synthesize β-aryl α,β-enones by fine-tuning the Pd(ii)-catalyzed oxidation of allyl alcohol to subsequent arylation with arylboronic acids, arylboronic ester and aryltrifluoroborate salt. This one-pot green method does not require copper salt, base, and intermediate isolation. Halogen-bearing chalcones, dibenzylideneacetones and arylalkyl enones were synthesized in good yields. This journal is

Accessing near-infrared-absorbing BF2-azadipyrromethenes via a push-pull effect

Novel aza-BODIPYs with significant bathochromic shifts were designed and synthesized by installation of strong electron-withdrawing groups on the para-positions of 1,7-phenyls and electron-donating groups on the para-positions of 3,4-phenyls. These dyes s

NUCLEAR RECEPTOR MODULATORS AND THEIR USE FOR THE TREATMENT AND PREVENTION OF CANCER

Disclosed are compounds which are nuclear receptor modulators that can act as antagonists to the androgen receptor, for example, a compound of Formula I: wherein R1 to R5 and X1 to X5 are as described herein, as well as pharmaceutically acceptable salts, solvates, and stereoisomers thereof. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment for cancers, including prostate cancers, other nuclear receptor mediated cancers, and other conditions, are also disclosed.

Microwave-accelerated coupling-isomerization-enamine addition-aldol condensation sequences to 1-acetyl-2-amino-cyclohexa-1,3-dienes

The microwave-accelerated consecutive reaction of electron deficient (hetero)aryl bromides 1, (hetero)aryl propargyl alcohols 2, and enamino carbonyl compounds 6 or 8 furnishes 1-acetyl-2-amino-cyclohexa-1,3-dienes 7 or 6-N,N-dimethyl carbamoyl-cyclohexen

Antimalarial alkoxylated and hydroxylated chalones: Structure-activity relationship analysis

Chalcones with 2′,3′,4′-trimethoxy, 2′,4′-dimethoxy, 4′-methoxy, 4′-ethoxy, 2′,4′-dihydroxy, and 4′-hydroxy groups on ring B were synthesized and evaluated in vitro against Plasmodium falciparum (K1) in a [3H] hypoxanthine uptake assay. The other ring A was quinoline, pyridine, naphthalene, or phenyl rings with electron-donating or electron-withdrawing substituents of varying lipophilicities. Trimethoxy 6 and 27, dimethoxy 7, 8, 29, and methoxy 31 analogues had good in vitro activities (IC50 5μM). 3-Quinolinyl ring A derivatives were well represented among the active compounds. Hydroxylated chalcones were less active than the corresponding alkoxylated analogues. When evaluated in vivo, 8 and 208 were comparable to chloroquine in extending the lifespan of infected mice. Multivariate data analysis showed that in vitro activity was mainly determined by the properties of ring B. Quantitative structure - activity relationship models with satisfactory predictive ability were obtained for various B ring chalcones using projections to latent structures. A model with good predictability was proposed for 19 active chalcones. Size and hydrophobicity were identified as critical parameters.

MESOGENIC AND NON MESOGENIC CENTRAL RIGID CORES.

The mesogenic power of several central rigid cores is measured by means of depolarized Rayleigh scattering. It is shown that there is a close relation between the angular correlation parameter J and the mesogenic power that lead us to define mesogenic and