74261-28-2

Usage

Chemical compound

4-[2-(4-methoxyphenyl)cyclopropyl]benzonitrile

Class

Benzonitrile derivatives

Physical state

White to off-white solid

Use

Organic synthesis and medicinal chemistry

Functional groups

Cyclopropyl group
Phenyl ring
Benzonitrile group
Methoxy group

Biological properties

Studied for potential use in drug development and pharmaceuticals

Upstream product

• 62584-59-2 1-<4-Methoxy-phenyl>-3-<4-cyan-phenyl>-propen-1-on 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 637-69-4 4-Methoxystyrene 
• 41780-79-4 N'-(4-cyanobenzylidene)-4-methylbenzenesulfonohydrazide 
• 105-07-7 4-cyanobenzaldehyde 
• 544-92-3 copper(I) cyanide 
• 77153-50-5 1-(p-chlorophenyl)-2-(p-methoxyphenyl)cyclopropane 

Relevant academic research and scientific papers

Electrochemical Ring-Opening Dicarboxylation of Strained Carbon-Carbon Single Bonds with CO2: Facile Synthesis of Diacids and Derivatization into Polyesters

Diacids are important monomers in the polymer industry to construct valuable materials. Dicarboxylation of unsaturated bonds, such as alkenes and alkynes, with CO2 has been demonstrated as a promising synthetic method. However, dicarboxylation of C-C single bonds with CO2 has rarely been investigated. Herein we report a novel electrochemical ring-opening dicarboxylation of C-C single bonds in strained rings with CO2. Structurally diverse glutaric acid and adipic acid derivatives were synthesized from substituted cyclopropanes and cyclobutanes in moderate to high yields. In contrast to oxidative ring openings, this is also the first realization of an electroreductive ring-opening reaction of strained rings, including commercialized ones. Control experiments suggested that radical anions and carbanions might be the key intermediates in this reaction. Moreover, this process features high step and atom economy, mild reaction conditions (1 atm, room temperature), good chemoselectivity and functional group tolerance, low electrolyte concentration, and easy derivatization of the products. Furthermore, we conducted polymerization of the corresponding diesters with diols to obtain a potential UV-shielding material with a self-healing function and a fluorine-containing polyester, whose performance tests showed promising applications.

Kinetic Study of the Homolytic Brominolysis of 1,2-Diarylcyclopropanes

The rate constants for the photolytic brominolysis of 22 trans-1,2-diarylcyclopropanes in carbon disulfide relative to an internal standard, p-chlorotoluene, have been determined.The products of the brominolysis are 1,3-dibromo-1,3-diarylpropanes.The rate constants range over 5 orders of magnitude, being enhanced by electrondonating substituents on one or both benzene rings.The quantitative size of the substituent effect (ρ) at either involved carbon center is a function of the substituent at the other center.This fact suggests a continuum of transition-state structures with varying degrees of bond breaking and charge separation.

MESOGENIC AND NON MESOGENIC CENTRAL RIGID CORES.

The mesogenic power of several central rigid cores is measured by means of depolarized Rayleigh scattering. It is shown that there is a close relation between the angular correlation parameter J and the mesogenic power that lead us to define mesogenic and