62593-77-5

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
N1-(4-Chloro-2-methylphenyl)-2-chloroacetamide is used as a chemical intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Antimicrobial Applications:
N1-(4-Chloro-2-methylphenyl)-2-chloroacetamide may exhibit biological activity as an antimicrobial agent, making it a potential candidate for use in the development of new antibiotics or antimicrobial products. Its ability to target and inhibit the growth of harmful microorganisms could contribute to the fight against antibiotic-resistant bacteria.
Used in Antifungal Applications:
As an antifungal agent, N1-(4-Chloro-2-methylphenyl)-2-chloroacetamide can be used in the development of new antifungal drugs or products. Its potential to inhibit the growth of fungi makes it a valuable compound in addressing fungal infections and controlling the spread of fungal diseases in various settings.
Used in Herbicidal Applications:
N1-(4-Chloro-2-methylphenyl)-2-chloroacetamide may also serve as a herbicidal agent, with potential applications in agriculture. Its ability to control the growth of unwanted plants and weeds could contribute to more efficient and effective crop management practices.
Used in Materials Science:
In the field of materials science, N1-(4-Chloro-2-methylphenyl)-2-chloroacetamide can be utilized as a component in the development of new materials with specific properties. Its unique structure and reactivity may contribute to the creation of advanced materials with applications in various industries.

InChI:InChI=1/C9H9Cl2NO/c1-6-4-7(11)2-3-8(6)12-9(13)5-10/h2-4H,5H2,1H3,(H,12,13)

Upstream product

• 79-04-9 chloroacetyl chloride 
• 95-69-2 4-chloro-2-methylbenzeneamine 
• 95-53-4 o-toluidine 

Downstream Products

• 77966-47-3 N,N-diethyl-glycine-(4-chloro-2-methyl-anilide); hydrochloride 

Relevant academic research and scientific papers

Synthesis and Biological Evaluation of Dithiobisacetamides as Novel Urease Inhibitors

Thirty-eight disulfides containing N-arylacetamide were designed and synthesized in an effort to develop novel urease inhibitors. Biological evaluation revealed that some of the synthetic compounds exhibited strong inhibitory potency against both cell-free urease and urease in intact cell with low cytotoxicity to mammalian cells even at concentration up to 250 μM. Of note, 2,2′-dithiobis(N-(2-fluorophenyl)acetamide) (d7), 2,2′-dithiobis(N-(3,5-difluorophenyl)acetamide) (d24), and 2,2′-dithiobis(N-(3-fluorophenyl)acetamide) (d8) were here identified as the most active inhibitors with IC50 of 0.074, 0.44, and 0.81 μM, showing 32- to 355-fold higher potency than the positive control acetohydroxamic acid. These disulfides were confirmed to bind urease without covalent modification of the cysteine residue and to inhibit urease reversibly with a mixed inhibition mechanism. They also showed very good anti-Helicobacter pylori activities with d8 showing a comparable potency to the clinical used drug amoxicillin. The impressive in vitro biological profile indicated their immense potential as therapeutic agents to tackle H. pylori caused infections.

A PROCESS FOR THE SYNTHESIS OF ANTHRANILIC ACID/AMIDE COMPOUNDS AND INTERMEDIATES THEREOF

The present invention discloses a process for the synthesis of compound of formula (VII) or a salt thereof, wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).

Design, synthesis of new pyrimidine derivatives as anticancer and antimicrobial agents

A new series of 6-aryl-5-cyano thiouracil derivatives were synthesized. Cyanouracil 1 was condensed with monochloroacetic acid and different aldehydes to give thiazolopyrimidine 2. On the other hand, treatment of cyanouracil 1 with 2-chloro-N-substituted-phenylac etamide afforded 4. Hydrazinolysis of 6 afforded the hydrazino derivatives 7 which upon reaction with different electrophilic reagents such as acetic anhydride, benzoyl chloride, and carbon disulfide yielded pyrimidine derivatives 8–15. Some of the new derivatives were explored for their antimicrobial activities. Compounds 7 and 9 have a promising activity, relatively equipotent to the reference drug. All of the new synthesized compounds were tested in vitro for their antiproliferative activities against HePG-2 and MCF-7 cell lines. Compounds 7, 9, and 2d displayed potent growth inhibitory effect toward the two cell lines more than the standard drug 5-FU. Furthermore, a docking study of the most active compounds was performed with thymidylate synthase enzyme.

COMPOUNDS USEFUL AS ANTIBIOTIC TOLERANCE INHIBITORS

The disclosure provides compounds and pharmaceutical compositions of the compounds useful for treating chronic and acute bacterial infections. Certain of the compounds are compounds and salts of general Formula VIII Certain compounds of this disclosure are MvfR inhibitors. MvfR inhibitors reduce the formation of antibiotic tolerant bacterial strains and are useful for treating Gram-negative bacterial infections and reducing the virulence of Pseudomonas aeruginosa. Methods of treating bacterial infections in a patient, including Pseudomonas aeruginosa infections, are also provided by the disclosure.