62613-59-6Relevant academic research and scientific papers
Programmable genotoxic agents and uses therefor
-
, (2008/06/13)
The compositions and methods disclosed herein provide heterobifunctional programmable genotoxic compounds that can be designed to kill selected cells present in a heterogenous cell population. The present compounds comprise a first agent that inflicts damage on cellular DNA, and a second agent that attracts a macromolecular cell component such as a protein, which in turn shields genomic lesions from repair. Unrepaired lesions therefore persist in the cellular genome and contribute to the death of selected cells. In contrast, lesions formed in nonselected cells, which lack the cell component, are unshielded and thus are repaired. As a result, compounds described herein are less toxic to nonselected cells. Compounds of this invention can be designed to cause the selective killing of transformed cells, viral-infected cells and the like.
2-Phenylindoles. Relationship between Structure, Estrogen Receptor Affinity, and Mammary Tumor Inhibiting Activity in the Rat
Angerer, Erwin von,Prekajac, Jelica,Strohmeier, Josef
, p. 1439 - 1447 (2007/10/02)
A number of 2-phenylindole derivatives with one hydroxy group in the meta or para position of the phenyl ring and a second one in position 5, 6, or 7 of the indole nucleus were synthesized.In addition, different alkyl groups were introduced into positions
2-Phenyl-indole derivatives
-
, (2008/06/13)
The present invention relates to new stabilizers of polymers and co-polymers of vinyl chloride corresponding to the general formula: STR1 wherein R1, R2, R3, R4, R5 and R6, which are the sa
