62613-80-3

Usage

InChI:InChI=1/C8H11NO4/c1-2-13-8(12)5-9-4-6(10)3-7(9)11/h2-5H2,1H3

Upstream product

• 13176-46-0 4-bromoethyl acetoacetate 
• 623-33-6 glycine ethyl ester hydrochloride 
• 110104-61-5 ethyl (2,5-dihydro-4-methoxy-2-oxo-1H-pyrrol-1-yl)acetate 

Downstream Products

• 61516-73-2 2-(oxo-pyrrolidin-1-yl)-acetic acid ethyl ester 
• 62613-81-4 ethyl (4-hydroxy-2-oxopyrrolidin-1-yl)acetate 
• 77191-37-8 4-hydroxy-2-oxo-1-pyrrolidine acetic acid 
• 105240-65-1 3-(1-(ethoxycarbonylmethyl)-2-oxo-3-pyrrolin-4-yl)-1-(ethoxycarbonylmethyl)-4-hydroxy-2-oxo-3-pyrroline 
• 141581-90-0 1-ethoxycarbonylmethyl-3-phenylhydrazinomethylenepyrrolidine-2,4-dione 
• 141581-87-5 1-ethoxycarbonylmethyl-3-benzylaminomethylenepyrrolidine-2,4-dione 
• 141581-91-1 2-ethoxycarbonylmethyl-3-oxo-6-phenyl-1,2-dihydro-3H-pyrrolo<3,4-c>pyrazole 
• 141581-89-7 1-carbamoylmethyl-3-benzylaminomethylenepyrrolidine-2,4-dione 
• 141581-88-6 1-carbamoylmethyl-3-aminomethylenepyrrolidine-2,4-dione 

Relevant academic research and scientific papers

Oxiracetam synthesis technology

The invention belongs to the field of pharmaceutical chemicals and particularly relates to an oxiracetam synthesis technology, ethyl acetoacetate and glycine are taken as the raw materials, the ethyl acetoacetate is changed into 4-halogeneated ethyl acetoacetate by halogenation reaction, the 4-halogeneated ethyl acetoacetate and glycine ester formed by the glycine are cyclized to form 2,4-dioxo-1-pyrrolidine acetate, and 4-hydroxy-2-oxo-1-pyrrolidineacetamide is obtained after hydrolysis and aminolysis. According to the oxiracetam synthesis technology, the related raw materials are easy to obtain, and the synthesis technology is simple and has good industrial values.

Process for the production of 4-hydroxy-2-oxopyrrolidin-1-yl-acetamide

Process for the production of 4-hydroxy-2-oxoyrrolidin-1-yl-acetamide, a cerebrally active pharmaceutical agent. A 4-halo-3-alkoxy-butenoic acid ester is reacted with glycine to new intermediate products of the formula: STR1 There is further by acid hydrolysis of the alkoxy group, subsequent hydrogenation, esterification of the carboxyl function and finally conversion to the end product by reaction with ammonia.

Process for the production of 4-hydroxy-2-oxo-pyrrolidin-1-yl acetamide

Process for the production of 4-hydroxy-2-oxo-pyrrolidin-1-yl acetamide. A 4-(C1 -C2)-alkoxy-3-pyrrolin-2-on-1-yl-acetic acid (C1 -C4)-alkyl ester of the formula: STR1 wherein R1 is alkyl having 1 or 2 C atoms and R2 is alkyl having 1 to 4 C atoms, is reacted with either trichloromethylsilane in the presence of an alkali iodide or in an acid anhydrous medium to a 2,4-dioxo-pyrrolidin-1-yl-acetic acid (C1 -C4)-alkyl ester. The latter is optionally isolated and then hydrogenated with sodium borohydride to a 4-hydroxy-2-oxo-pyrrolidin-1-yl-acetic acid (C1 -C4)-alkyl ester. Finally, the 4-hydroxy-2-oxo-pyrrolidin-1-yl-acetic acid (C1 -C4)-alkyl ester is converted by amidation with ammonia to the desired end product.