62625-23-4Relevant articles and documents
3-Acetoxy-fatty acid isoprenyl esters from androconia of the ithomiine butterfly Ithomia salapia
Elias, Marianne,Mann, Florian,McClure, Melanie,Schulz, Stefan,Silva, Lisa de,Szczerbowski, Daiane
supporting information, p. 2776 - 2786 (2020/12/29)
Male ithomiine butterflies (Nymphalidae: Danainae) have hairpencils on the forewings (i.e., androconia) that disseminate semiochemicals during courtship. While most ithomiines are known to contain derivatives of pyrrolizidine alkaloids, dihydropyrrolizines, or ?-lactones in these androconia, here we report on a new class of fatty acid esters identified in two subspecies, Ithomia salapia aquinia and I. s. derasa. The major components were identified as isoprenyl (3-methyl-3-butenyl) (Z)-3-acetoxy-11-octadecenoate, isoprenyl (Z)-3-acetoxy-13-octadecenoate (12) and isoprenyl 3-acetoxyoctadecanoate (11) by GC/MS and GC/IR analyses, microderivatizations, and synthesis of representative compounds. The absolute configuration of 12 was determined to be R. The two subspecies differed not only in the composition of the ester bouquet, but also in the composition of more volatile androconial constituents. While some individuals of I. s. aquinia contained ithomiolide A (3), a pyrrolizidine alkaloid derived ?-lactone, I. s. derasa carried the sesquiterpene a-elemol (8) in the androconia. These differences might be important for the reproductive isolation of the two subspecies, in line with previously reported low gene exchange between the two species in regions where they co-occur. Furthermore, the occurrence of positional isomers of unsaturated fatty acid derivatives indicates activity of two different desaturases within these butterflies, ?9 and ?11, which has not been reported before in male Lepidoptera.
Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases
Sbardella, Gianluca,Castellano, Sabrina,Vicidomini, Caterina,Rotili, Dante,Nebbioso, Angela,Miceli, Marco,Altucci, Lucia,Mai, Antonello
, p. 2788 - 2792 (2008/12/23)
Pentadecylidenemalonate 1b, a simplified analogue of anacardic acid, was identified as the first mixed activator/inhibitor of histone acetyltransferases (HATs). It potentiates PCAF HAT activity while inhibiting those of p300/CBP and recombinant CBP. The remarkable apoptotic effect together with the ability to selectively acetylate histone versus non-histone substrates appoint 1b as a lead for the development of anticancer drugs.
An efficient selective oxidation of alcohols with potassium permanganate adsorbed on aluminum silicate under solvent-free conditions and shaking
Lou, Ji-Dong,Gao, Chun-Ling,Li, Li,Fang, Zhi-Gang
, p. 1071 - 1074 (2007/10/03)
A new procedure for the selective oxidation of alcohols to the corresponding aldehydes and ketones with potassium permanganate supported on aluminum silicate at room temperature under solvent-free conditions and shaking is reported. Springer-Verlag 2006.