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Usage

Uses

Used in Scientific Research:
N-(2-HYDROXYETHYL)ISONICOTINAMIDE, 99 is used as a research chemical for various applications in the fields of chemistry and biochemistry. Its unique structure and properties make it a valuable compound for studying chemical reactions and interactions at the molecular level.
Used in Chemical Synthesis:
In the chemical industry, N-(2-HYDROXYETHYL)ISONICOTINAMIDE, 99 can be used as an intermediate or a building block in the synthesis of more complex molecules. Its presence of the 2-hydroxyethyl group provides opportunities for further chemical modifications and the creation of new compounds with potential applications in various industries.
Used in Pharmaceutical Development:
N-(2-HYDROXYETHYL)ISONICOTINAMIDE, 99 may also be utilized in the development of new pharmaceuticals. Its structure and properties could potentially contribute to the design of novel drug candidates, particularly in the area of vitamin B3-related therapies or other therapeutic applications where its chemical properties may be beneficial.
Used in Analytical Chemistry:
In analytical chemistry, N-(2-HYDROXYETHYL)ISONICOTINAMIDE, 99 can be employed as a reference compound or a standard for the calibration of analytical instruments. Its well-defined purity and chemical characteristics make it suitable for use in quality control and assurance processes within the industry.

InChI:InChI=1/C8H10N2O2/c11-6-5-10-8(12)7-1-3-9-4-2-7/h1-4,11H,5-6H2,(H,10,12)

Upstream product

• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 141-43-5 ethanolamine 
• 1570-45-2 isonicotinic acid ethylester 
• 55-22-1 pyridine-4-carboxylic acid 

Downstream Products

• 868368-43-8 fac-[(N-2-hydroxyethyl-isonicotinamide)(1,2-bis(diphenylphosphino)ethane)tricarbonylmanganese(I)] triflate 
• 65141-47-1 N-(2-nitroxyethyl)isonicotinamide 
• 13841-66-2 butyl isonicotinate 

Relevant academic research and scientific papers

Synthesis of Functionalized Pyridines via a Regioselective Oxazoline Promoted C-H Amidation Reaction

The first Rh-catalyzed C-H amidation of pyridines is reported. The incorporation of a substituent at the C2 position both is crucial to the success of this transformation and provides considerable scope for further elaboration of the resulting products. Among these compounds, 2-chloropyridines allow access to a selection of intermediates including a versatile azaquinazoline scaffold.

Synthesis, antinociceptive activity and pharmacokinetic profiles of nicorandil and its isomers

Nicorandil (N-(2-hydroxyethyl)nicotinamide nitrate) is an antianginal drug, which activates guanylyl cyclase and opens the ATP-dependent K+ channels, actions that have been suggested to mediate its vasodilator activity. We synthesized nicorandil and its two isomers, which vary in the positions of the side chain containing the nitric oxide (NO) donor, and also their corresponding denitrated metabolites. The activities of these compounds were evaluated in an experimental model of pain in mice. Pharmacokinetic parameters of nicorandil and its isomers, as well as the plasma concentrations of the corresponding denitrated metabolites and also nicotinamide and nitrite were determined. Nicorandil exhibited the highest antinociceptive activity, while the ortho-isomer was the least active. Nicorandil and para-nicorandil, which induced higher plasma concentrations of nitrite, exhibited higher antinociceptive activity, which suggests that the release of NO may mediate this activity.

Study of synthesis and cardiovascular activity of some furoxan derivatives as potential NO-donors

A series of hybrid molecules incorporating the furoxan and nicorandil moieties were designed as potential NO donors with cardiovascular and cerebrovascular activities. Thirty-six target molecules were successfully synthesized by conventional methods and characterized by infrared spectroscopy, 1H-NMR spectroscopy and high resolution mass spectra. The compounds were tested for their effects on KCl-induced contraction of rabbit thoracic aorta whose endothelium was denuded. Eight compounds were found to reduce KCl-induced contraction by more than 30% at 10 μM. All except one of these compounds are characterized by the presence of electron withdrawing groups in the phenyl ring attached via an amide or ester linkage to the furoxan moiety. The nature of the terminal carbonyl linkage (ester or amide) and the length or type of the alkyl chain bridging the two carbonyl functions have little effect on the activity. One of the active compounds, N-(4- methoxy-benzoyl)-N'-[3-methylfuroxanyl-4-carbonyl)piperazine (17i) was tested for hypotensive effects on anaesthetized rats at 1.5 mg/kg, and found to demonstrate a gradual and sustained hypotensive effect. The results suggest that the furoxannicorandil derivatives are a useful lead in the design of NO- donor compounds for hypertension.

Reactions of Hydroxy Carboxylic Acid Amides and Their O-Trimethylsilyl Derivatives with Chloro(chloromethyl)-dimethylsilane. Synthesis of 1-Oxa-4-aza-2-sila-and 1-Oxa-4-aza-2,6-disilacyclohexanes

A general strategy has been developed for the synthesis of 1-oxa-4-aza-2-silacyclohexanes, 1-oxa-4-aza-2-silacyclohexan-5-ones, and 4-acyl-1-oxa-4-aza-2-silacyclohexanes from carboxylic acid amides containing a hydroxy group in the acid and/or amide moiety via two routes. The first of these includes transformation of N-monosubstituted carboxamides into corresponding O-trimethylsilyl derivatives which react with chloro(chloromethyl)dimethylsilane in the presence of a base to form unstable N-chlorodimethylsilyl-methyl amide derivatives with a five-coordinate silicon atom. Thermal decomposition of the latter during fractionation yields the target silicon-containing heterocycles with an OSiCH2N fragment. The second route consists of direct treatment of N-monosubstituted carboxamides with a mixture of hexamethyldisilazane and chloro(chloromethyl)dimethylsilane, which results in formation of 1-oxa-4-aza-2-silacyclohexan-5-ones and 4-acyl-1-oxa-4-aza-2-silacyclohexanes in high yields, thus excluding preliminary O-silylation of the starting hydroxy amides. One-pot reactions of N-unsubstituted carboxylic acid amides with a hexamethyldisilazane-chloro(chloromethyl)dimethylsilane mixture, followed by hydrolysis, yield 4-acyl-1-oxa-4-aza-2,6-disilacyclohexanes.

Use of N-acyl derivatives of aminoalcohols for the manufacture of a medicament for the treatment of pathologies involving mast cells

N-acyl-derivatives of amino alcohols suitable for the therapeutic treatment of pathologies characterized by degranulation of mast cells caused by a neurogen and/or immunogenic hyperstimulation.