6269-30-3

Upstream product

• 141-79-7 4-methyl-pent-3-en-2-one 
• 108-90-7 chlorobenzene 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 637-87-6 1-Chloro-4-iodobenzene 
• 30568-32-2 2-(4-chlorophenyl)-2-methylpropanenitrile 
• 2386-64-3 ethylmagnesium chloride 
• 17333-85-6 4-chlorophenyldiazonium salt 

Downstream Products

• 479070-58-1 4-(4-chlorophenyl)-2,4-dimethylpentan-2-ol 

Relevant academic research and scientific papers

MODULATORS FOR AMYLOID BETA

The invention relates to compounds of formula wherein the substituents are as described in claim 1. Compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposi

On rearrangements by cyclialkylations of arylpentanols to 2,3-dihydro-1H-indene derivatives. Part 1. An unexpected rearrangement by the acid-catalyzed cyclialkylation of 4-(2-chlorophenyl)-2,4-dimethyl pentan-2-ol under formation of trans-4-chloro-2,3-dih

The acid-catalyzed cyclialkylation of 2,4-dimethyl-4-phenylpentan-2-ol led exclusively to the expected product, 2,3-dihydro-1,1,3,3-tetramethyl-1H-indene. However, analogous cyclialkylation of 4-(2-chlorophenyl)-2,4-dimethylpentan-2-ol (1) gave a ca. 1:1

Preparation and reactivity of functionalized aryl and alkenylmanganese halides

Various functionalized aryl and alkenyl manganese halides have been prepared from the corresponding aryl and alkenylhalides according to a one-pot procedure: lithium-halogen exchange at low temperature then Li-Mn transmetallation.

Steric, Polar, and Resonace Effects in Reactivity and Regioselectivity of Aryl Radical Addition to α,β-Unsaturated Carbonyl Compounds

Free-radical decomposition of diazonium salts by titanous salts in the presence of olefins conjugated with carbonyl groups leads to reductive arylation or arylation and diazo coupling of the radical adduct, depending on the orientation of the aryl radical addition (β or α).The absolute rate constants of the addition (107 - 108 M-1s-1 at 5 deg C) were determined by comparison with the rate of the iodine abstraction by aryl radicals from isopropyl iodide.The obtained data of the addition rates to the β position correlate well with the Es steric parameters.The influence of the resonace stabilization of the radical adduct on the reactivity can be significant, but the regioselectivity of the addition is mainly determined by steric effects.The different fate of the α- and β-radical adducts are discussed on the basis of their different polar character.