62697-87-4

Basic information

• Product Name: L-Histidine, N-[(1,1-dimethylethoxy)carbonyl]-1-(triphenylmethyl)-, methyl ester
• CAS NO: 62697-87-4
• Molecular Formula: C31H33N3O4
• Molecular Weight: 511.621
• Mol File: 62697-87-4.mol

Chemical Properties

• CAS DataBase Reference: L-Histidine, N-[(1,1-dimethylethoxy)carbonyl]-1-(triphenylmethyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Histidine, N-[(1,1-dimethylethoxy)carbonyl]-1-(triphenylmethyl)-, methyl ester(62697-87-4)
• EPA Substance Registry System: L-Histidine, N-[(1,1-dimethylethoxy)carbonyl]-1-(triphenylmethyl)-, methyl ester(62697-87-4)

Safety Data

• Hazardous Substances Data: 62697-87-4(Hazardous Substances Data)

Upstream product

• 76-83-5 trityl chloride 
• 68262-63-5 N^α-benzyloxycarbonyl-N^im-triphenylmethyl-L-histidine methyl ester 
• 14997-58-1 N-[(benzyloxy)carbonyl]-L-histidine 
• 1499-46-3 L-Histidine methyl ester 
• 71-00-1 L-histidine 
• 40917-50-8 1,N^α-bis-benzyloxycarbonyl-histidine methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 62715-28-0 N^im-triphenylmethyl-L-histidine methyl ester 

Downstream Products

• 72212-51-2 (S)-methyl 2-(tert-butoxycarbonylamino)-3-(1-methyl-1H-imidazol-5-yl)propanoate 
• 176752-33-3 [3-({2'-[2-((2S,3R)-2-{(2S,3S,4R)-4-[(S)-2-tert-Butoxycarbonylamino-3-(1-trityl-1H-imidazol-4-yl)-propionylamino]-3-hydroxy-2-methyl-pentanoylamino}-3-hydroxy-butyrylamino)-ethyl]-[2,4']bithiazolyl-4-carbonyl}-amino)-propyl]-dimethyl-sulfonium 
• 176752-34-4 [3-({2'-[2-((2S,3R)-2-{(2S,3S,4R)-4-[(S)-2-Amino-3-(1-trityl-1H-imidazol-4-yl)-propionylamino]-3-hydroxy-2-methyl-pentanoylamino}-3-hydroxy-butyrylamino)-ethyl]-[2,4']bithiazolyl-4-carbonyl}-amino)-propyl]-dimethyl-sulfonium 
• 176752-32-2 N^α-[(tert-butyloxy)carbonyl]-N^β-[3(S)-[4-amino-6-[[[1-(S)-(({4(S)-[({1(S)-[({2-[4'-({[3-(dimethylsulfonio)-1-propyl]amino}carbonyl)-2',4-bithiazol-2-yl]-1-ethyl}amino)carbonyl]-2(R)-hydroxy-1-propyl}amino)carbonyl]-3(S)-hydroxy-2(R)-pentyl}amin... 
• 73086-38-1 N(α)-tert-butoxycarbonyl-N(?)-phenacyl-L-histidine methyl ester 
• 2488-14-4 N-(tert-butoxycarbonyl)-L-histidine methyl ester 
• 79950-77-9 N^α-tert-Boc-N^?-<(benzyloxy)methyl>-L-histidine methyl ester 
• 32926-43-5 N^α-(tert-butyloxy)carbonyl-N^im-triphenylmethyl-L-histidine 
• 111102-61-5 N-(t-Butoxycarbonyl)-3-(4-nitrobenzyl)-L-histidine methyl ester 

Relevant articles and documents

NOVEL HISTIDINE DERIVATIVE

The present invention is to provide a novel compound which is useful as an excellent analgesic agent. The present invention is to provide the novel histidine derivative having an excellent analgesic action and the like. The compound of the present inventi

Synthesis and evaluation of deglycobleomycin A2 analogues containing a tertiary N-methyl amide and simple ester replacement for the L-histidine secondary amide: Direct functional characterization of the requirement for secondary amide metal complexation

The synthesis and comparative examination of 3-5, analogues of deglycobleomycin A2 (2) which address the inferred importance of the L-histidine secondary amide directly, are detailed. The agent 3 lacks only the L-histidine β-hydroxy group of deglycobleomycin A2 and the corresponding agents 4 and 5 incorporate a tertiary N-methyl amide and simple ester in place of the L-histidine secondary amide. The DNA cleavage properties of 3 proved essentially indistinguishable from those of deglycobleomycin A2 (2) confirming that the distinctions between bleomycin A2 (1) and deglycobleomycin (2) are due to the removal of the disaccharide and not the introduction of the L-histidine free β-hydroxy group. The agents 4 and 5 containing a tertiary N-methyl amide and ester in place of the L-histidine secondary amide were found to cleave duplex DNA but to do so in a nonsequence selective fashion with a substantially reduced efficiency and a diminished double to single strand cleavage ratio that are only slightly greater than that of free iron itself. These latter observations establish the functional requirement for the L-histidine secondary amide and are consistent with the proposals that the L-histidine deprotonated secondary amide is required for functional metal chelation and activity.