72212-51-2

Usage

Uses

Used in Organic Synthesis:
(S)-methyl 2-(tert-butoxycarbonylamino)-3-(1-methyl-1H-imidazol-5-yl)propanoate is used as a key intermediate for the synthesis of various complex organic molecules, leveraging its unique structural features to facilitate the formation of desired products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (S)-methyl 2-(tert-butoxycarbonylamino)-3-(1-methyl-1H-imidazol-5-yl)propanoate is used as a building block for the development of novel drugs, potentially targeting a range of therapeutic areas due to its versatile chemical structure.
Used in Biotechnology:
(S)-methyl 2-(tert-butoxycarbonylamino)-3-(1-methyl-1H-imidazol-5-yl)propanoate is utilized as a component in the design of bioactive molecules, with potential applications in the creation of new biocatalysts, biosensors, or other biotechnological tools.
It is crucial to handle and use (S)-methyl 2-(tert-butoxycarbonylamino)-3-(1-methyl-1H-imidazol-5-yl)propanoate with care, adhering to proper safety protocols and guidelines to ensure safe and effective utilization of (S)-methyl 2-(tert-butoxycarbonylamino)-3-(1-methyl-1H-imidazol-5-yl)propanoate in various applications.

Upstream product

• 62697-87-4 N^α-(tert-butyloxy)carbonyl-N^im-triphenylmethyl-L-histidine methyl ester 
• 121056-95-9 trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate 
• 67-56-1 methanol 
• 61070-22-2 Boc-L-(?-Me)-His-OH 
• 333-27-7 methyl trifluoromethanesulfonate 
• 2488-14-4 (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(1H-imidazol-4-yl)propanoate 
• 945386-72-1 4-(2-tert-butoxycarbonylamino-2-methoxycarbonylethyl)-3-methyl-1-trityl-3H-imidazolyl-1-ium iodide 

Downstream Products

• 1287776-56-0 nosyl-(?-Me)-L-His-OMe 
• 1287776-57-1 tosyl-(?-Me)-L-His-OMe 
• 1287776-60-6 nosyl-(?-Me)-L-His-OH 
• 1287776-61-7 tosyl-(?-Me)-L-His-OH 
• 1287776-42-4 mesyl-(?-Me)-L-His-D-Pro-Aib-L-Phe-OMe 
• 1287776-43-5 nosyl-(?-Me)-L-His-D-Pro-Aib-L-Phe-OMe 
• 1287776-44-6 tosyl-(?-Me)-L-His-D-Pro-Aib-L-Phe-OMe 
• 1287776-45-7 mesyl-(?-Me)-L-His-D-Pro-CSNH-Aib-L-Phe-OMe 
• 1287776-46-8 nosyl-(?-Me)-L-His-D-Pro-CSNH-Aib-L-Phe-OMe 
• 1287776-47-9 tosyl-(?-Me)-L-His-D-Pro-CSNH-Aib-L-Phe-OMe 

Relevant academic research and scientific papers

Concise Synthesis of Anserine: Efficient Solvent Tuning in Asymmetric Hydrogenation Reaction

A concise synthesis of anserine and related compounds was accomplished by Et-DuPhos-Rh-catalyzed asymmetric hydrogenation of dehydrohistidine derivatives in 2,2,2-trifluoroethanol, which played a key role in improving the yield and selectivity.

The Enantioselective Dakin-West Reaction

Here we report the development of the first enantioselective Dakin-West reaction, yielding α-acetamido methylketones with up to 58 % ee with good yields. Two of the obtained products were recrystallized once to achieve up to 84 % ee. The employed methylimidazole-containing oligopeptides catalyze both the acetylation of the azlactone intermediate and the terminal enantioselective decarboxylative protonation. We propose a dispersion-controlled reaction path that determines the asymmetric reprotonation of the intermediate enolate after the decarboxylation.

Development of a regioselective N-methylation of (benz)imidazoles providing the more sterically hindered isomer

An efficient and highly regioselective N-methylation of (NH)-(benz)imidazoles furnishing the sterically more hindered, less stable, and usually minor regioisomer has been developed. The methodology involves very mild reaction conditions and tolerates a wide range of functional groups.

NOVEL HISTIDINE DERIVATIVE

The present invention is to provide a novel compound which is useful as an excellent analgesic agent. The present invention is to provide the novel histidine derivative having an excellent analgesic action and the like. The compound of the present inventi