627-36-1Relevant academic research and scientific papers
Synthesis and structure–activity relationship of α-keto amides as enterovirus 71 3C protease inhibitors
Zeng, Debin,Ma, Yuying,Zhang, Rui,Nie, Quandeng,Cui, Zhengjie,Wang, Yaxin,Shang, Luqing,Yin, Zheng
supporting information, p. 1762 - 1766 (2016/12/22)
α-Keto amide derivatives as enterovirus 71 (EV71) 3C protease (3Cpro) inhibitors have been synthesized and assayed for their biochemical and antiviral activities. structure–activity relationship (SAR) study indicated that small moieties were primarily tolerated at P1' and the introduction of para-fluoro benzyl at P2 notably improved the potency of inhibitor. Inhibitors 8v, 8w and 8x exhibited satisfactory activity (IC50= 1.32 ± 0.26 μM, 1.88 ± 0.35 μM and 1.52 ± 0.31 μM, respectively) and favorable CC50values (CC50> 100 μM). α-Keto amide may represent a good choice as a warhead for EV71 3Cproinhibitor.
The Question of Tautomerism of Alkylnitrile and Isonitrile Cations
Chess, Edward K.,Lapp, R. L.,Gross, Michael L.
, p. 475 - 480 (2007/10/02)
The isomeric pairs+. and +. and +. and +. have been established as stable, noninterconverting structures.The conclusion derives from studies of collision induced decomposition spectra.The same conclusion pertains for the ions +. and +., and for +., +. and HNCCHCHCNH>+..The energy barrier of a -hydrogen shift, a possible isomerization mechanism, is determined to be at least 163kJ mol-1 for the +. and +. pair, and the barrier may be as high as 318kJ*mol-1.The C3H5N and C4H4N2 radical cations decompose before they can be activated with 318 kJ mol-1 of internal energy.
