627-36-1

Basic information

• Product Name: propyl isocyanide
• Synonyms: propyl isocyanide;1-Isocyanopropane;2-Azonia-1-pentyne-1-ide
• CAS NO: 627-36-1
• Molecular Formula: C₄H₇N
• Molecular Weight: 0
• Mol File: 627-36-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 117.85°C (estimate)
• Appearance: /
• Density: 0.7526
• Refractive Index: 1.3805
• CAS DataBase Reference: propyl isocyanide(CAS DataBase Reference)
• NIST Chemistry Reference: propyl isocyanide(627-36-1)
• EPA Substance Registry System: propyl isocyanide(627-36-1)

Safety Data

• Hazardous Substances Data: 627-36-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H7N/c1-3-4-5-2/h3-4H2,1H3

Upstream product

• 506-64-9 silver(I) cyanide 
• 107-08-4 1-iodo-propane 
• 107-10-8 propylamine 
• 67-66-3 chloroform 
• 6281-94-3 N-propyl formamide 

Downstream Products

• 859075-87-9 benzoyloxy-phenyl-acetic acid propylamide 
• 1426687-67-3 N-(3-oxo-2-propyl-2,3-dihydroisoquinolin-4-yl)-N-(4-(trifluoromethyl)phenyl)picolinamide 
• 39077-95-7 S-benzyl N-propylthiocarbamate 
• 86015-63-6 triphenylphosphine(n-propylisocyanide)dicarbonyldibromoiron(II) 
• 85987-03-7 bis(n-propylisocyanide)carbonyldibromo(triphenylphosphine)iron(II) 
• 4824-13-9 N-carbobenzoxy-L-valine pentachlorophenyl ester 
• 1426687-90-2 N-(3-oxo-2-propyl-7-(trifluoromethyl)-2,3-dihydroisoquinolin-4-yl)-N-propylbenzamide 
• 1426687-94-6 N-(7-chloro-3-oxo-2-propyl-2,3-dihydroisoquinolin-4-yl)-N-(prop-2-ynyl)benzamide 
• 2873-37-2 -L-leucine methyl ester 

Relevant articles and documents

Synthesis and structure–activity relationship of α-keto amides as enterovirus 71 3C protease inhibitors

α-Keto amide derivatives as enterovirus 71 (EV71) 3C protease (3Cpro) inhibitors have been synthesized and assayed for their biochemical and antiviral activities. structure–activity relationship (SAR) study indicated that small moieties were primarily tolerated at P1' and the introduction of para-fluoro benzyl at P2 notably improved the potency of inhibitor. Inhibitors 8v, 8w and 8x exhibited satisfactory activity (IC50= 1.32 ± 0.26 μM, 1.88 ± 0.35 μM and 1.52 ± 0.31 μM, respectively) and favorable CC50values (CC50> 100 μM). α-Keto amide may represent a good choice as a warhead for EV71 3Cproinhibitor.