6281-94-3

Usage

InChI:InChI=1/C4H9NO/c1-2-3-5-4-6/h4H,2-3H2,1H3,(H,5,6)

Upstream product

• 107-10-8 propylamine 
• 86412-76-2 Rh(C₄₄H₂₈N₄)(CHO) 
• 64-18-6 formic acid 
• 108-03-2 1-Nitropropane 

Downstream Products

• 35668-73-6 3-phenyl-2-(Z)-propylimino-2,3-dihydro-benzo[e][1,3]thiazin-4-one 
• 35668-65-6 4-(E)-phenylimino-3-propyl-3,4-dihydro-benzo[e][1,3]thiazin-2-one 
• 32150-25-7 N²-n-propyl-N¹,N¹-dimethylformamidine 
• 68-12-2 N,N-dimethyl-formamide 
• 75-65-0 tert-butyl alcohol 
• 627-36-1 n-propyl isocyanide 
• 91585-53-4 Phenyl-propylaminomethyl-phosphinic acid 
• 107-10-8 propylamine 
• 627-35-0 methyl-n-propylamine 
• 39203-79-7 N-propylbenzothioamide 

Relevant academic research and scientific papers

Cobalt nanoparticles anchoring on nitrogen doped carbon with excellent performances for transfer hydrogenation of nitrocompounds to primary amines and N-substituted formamides with formic acid

Cobalt nanoparticles anchoring on nitrogen doped carbon derived from pyrolysis of a cobalt complex and chitosan were developed for reduction of nitrocompounds with neat formic acid to their corresponding amines or N-substituted formamides by switch of solvents. Characterization results revealed that most of the nitrogen atoms are present as graphitic N and pyridinic N as anchoring sites, and the cobalt nanoparticles are wrapped by nitrogen doped carbon layers, endowing the catalyst with excellent activity and superior reusability.

Production of Formamides from CO and Amines Induced by Porphyrin Rhodium(II) Metalloradical

It is of fundamental importance to transform carbon monoxide (CO) to petrochemical feedstocks and fine chemicals. Many strategies built on the activation of C≡O bond by π-back bonding from the transition metal center were developed during the past decades. Herein, a new CO activation method, in which the CO was converted to the active acyl-like metalloradical, [(por)Rh(CO)]? (por = porphyrin), was reported. The reactivity of [(por)Rh(CO)]? and other rhodium porphyrin compounds, such as (por)RhCHO and (por)RhC(O)NHnPr, and corresponding mechanism studies were conducted experimentally and computationally and inspired the design of a new conversion system featuring 100% atom economy that promotes carbonylation of amines to formamides using porphyrin rhodium(II) metalloradical. Following this radical based pathway, the carbonylations of a series of primary and secondary aliphatic amines were examined, and turnover numbers up to 224 were obtained.

Process for the preparation of formamides

Formamides e.g. diethylformamide are prepared by reacting a primary or secondary amine e.g. diethylamine or ammonia with (a) an alkyl formate or (b) carbon monoxide and an alkanol in the presence, as catalyst, of (i) a compound containing an amidine group or (ii) a Group V element-containing Lewis base and an epoxide. The Lewis base can be a trivalent nitrogen or phosphorus-containing compound. The amidine group which can be cyclic or acyclic can form part of a guanidine group.