340962-84-7

Basic information

• Product Name: 1-(1-benzylpiperidin-4-yl)-piperidin-2-one
• Synonyms: 1-(1-benzylpiperidin-4-yl)-piperidin-2-one
• CAS NO: 340962-84-7
• Molecular Weight: 272.39
• Mol File: 340962-84-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-(1-benzylpiperidin-4-yl)-piperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-benzylpiperidin-4-yl)-piperidin-2-one(340962-84-7)
• EPA Substance Registry System: 1-(1-benzylpiperidin-4-yl)-piperidin-2-one(340962-84-7)

Safety Data

• Hazardous Substances Data: 340962-84-7(Hazardous Substances Data)

Usage

Description

1-(1-benzylpiperidin-4-yl)-piperidin-2-one is a chemical compound with a molecular formula C17H24N2O. It is a piperidone derivative and belongs to the class of piperidine-containing compounds. 1-(1-benzylpiperidin-4-yl)-piperidin-2-one has garnered interest in the field of medicinal chemistry due to its potential pharmacological activities, including its role as an intermediate in the synthesis of various bioactive compounds. Its chemical structure and properties make it a valuable tool for drug discovery and development, and it has the potential to be used in the development of new pharmaceuticals for various therapeutic applications. Additionally, it may also serve as a useful starting material for the synthesis of other complex organic compounds.

Uses

Used in Pharmaceutical Industry:
1-(1-benzylpiperidin-4-yl)-piperidin-2-one is used as an intermediate for the synthesis of various bioactive compounds for [application reason] its potential pharmacological activities and valuable properties in drug discovery and development.
1-(1-benzylpiperidin-4-yl)-piperidin-2-one is used as a starting material for the synthesis of other complex organic compounds for [application reason] its potential to be used in the development of new pharmaceuticals for various therapeutic applications.
(Note: The specific application reasons are not provided in the materials, so they are left as placeholders to be filled in with the appropriate reasons based on the compound's properties and potential uses.)

Upstream product

• 675-20-7 piperidin-2-one 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 627-95-2 5-amino-valeric acid ; hydrochloride 
• 4509-90-4 5-bromovaleroyl chloride 
• 50541-93-0 4-amino-1-benzylpiperidine 

Downstream Products

• 543745-05-7 1-(1-benzyl-4-piperidinyl)-3-(4-morpholinyl)-5,6-dihydro-2(1H)-pyridinone 
• 543745-08-0 1-(4-methoxyphenyl)-7-oxo-6-(4-piperidinyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide 
• 543745-07-9 ethyl 1-(4-methoxyphenyl)-7-oxo-6-(piperidin-4-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 
• 543745-06-8 ethyl 6-(1-benzyl-4-piperidinyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 
• 543745-09-1 6-[1-(2-formylphenyl)-4-piperidinyl]-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide 
• 543745-10-4 1-(4-methoxyphenyl)-6-(1-{2-[(methylamino)methyl]phenyl}-4-piperidinyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide 
• 543745-04-6 1'-benzyl-3,3-dichloro-1,4'-bipiperidin-2-one 
• 159874-26-7 1-(piperidin-4-yl)piperidin-2-one 

Relevant articles and documents

PYRIDAZINONES AS PARP7 INHIBITORS

The present invention relates to pyridazinones and related compounds which are inhibitors of PARP7 and are useful in the treatment of cancer.

Discovery of a tetrahydropyrimidin-2(1 H)-one derivative (TAK-442) as a potent, selective, and orally active factor Xa inhibitor

Coagulation enzyme factor Xa (FXa) is a particularly promising target for the development of new anticoagulant agents. We previously reported the imidazo[1,5-c]imidazol-3-one derivative 1 as a potent and orally active FXa inhibitor. However, it was found that 1 predominantly undergoes hydrolysis upon incubation with human liver microsomes, and the human specific metabolic pathway made it difficult to predict the human pharmacokinetics. To address this issue, our synthetic efforts were focused on modification of the imidazo[1,5-c] imidazol-3-one moiety of the active metabolite 3a, derived from 1, which resulted in the discovery of the tetrahydropyrimidin-2(1H)-one derivative 5k as a highly potent and selective FXa inhibitor. Compound 5k showed no detectable amide bond cleavage in human liver microsomes, exhibited a good pharmacokinetic profile in monkeys, and had a potent antithrombotic efficacy in a rabbit model without prolongation of bleeding time. Compound 5k is currently under clinical development with the code name TAK-442.

Pyrazole-based factor Xa inhibitors containing N-arylpiperidinyl P4 residues

The synthesis, SAR, pharmacokinetic profile, and modeling studies of both monocyclic and fused pyrazoles containing substituted N-arylpiperidinyl P4 moieties that are potent and selective factor Xa inhibitors will be discussed. Fused pyrazole analog 16a,