6271-40-5

Usage

Uses

Used in Food Industry:
4a,5,8,8a-Tetrahydro-1,4-naphthoquinone is used as a vitamin K supplement for enhancing the nutritional value of food products.
Used in Cosmetic Industry:
4a,5,8,8a-Tetrahydro-1,4-naphthoquinone is used as a precursor for the synthesis of various pharmaceuticals and cosmetic ingredients, contributing to the development of skincare and other cosmetic products.
Used in Pharmaceutical Industry:
4a,5,8,8a-Tetrahydro-1,4-naphthoquinone is used as a precursor in the production of vitamin K and related compounds, which have various medicinal applications.
However, it is important to note that 4a,5,8,8a-Tetrahydro-1,4-naphthoquinone can be toxic in large doses and has been linked to liver damage and hemolytic anemia in some cases. Therefore, its use should be carefully regulated and monitored to ensure safety.

InChI:InChI=1/C10H10O2/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-2,5-8H,3-4H2

Upstream product

• 106-99-0 buta-1,3-diene 
• 106-51-4 p-benzoquinone 
• 71-43-2 benzene 
• 590-19-2 2,3-dimethylbutene 

Downstream Products

• 58851-76-6 4-acetyloxy-5,8-dihydronaphthalen-1-yl acetate 
• 55077-79-7 5,8-dimethoxy-1,4-dihydronaphthalene 
• 13623-10-4 5,6,7,8-tetrahydronaphthalene-1,4-diol 
• 58851-64-2 6,7-epoxy-5,6,7,8-tetrahydro-1,4-dimethoxynaphthalene 
• 37464-90-7 5,8-dimethoxy-2-tetralone 
• 58851-77-7 6-acetyloxy-1a,2,7,7a-tetrahydronaphtho[2,3-b]oxiren-3-yl acetate 
• 130-15-4 [1,4]naphthoquinone 

Relevant academic research and scientific papers

Acyclic cucurbit[n]uril-type molecular containers: Influence of aromatic walls on their function as solubilizing excipients for insoluble drugs

We studied the influence of the aromatic sidewalls on the ability of acyclic CB[n]-type molecular containers (1a-1e) to act as solubilizing agents for 19 insoluble drugs including the developmental anticancer agent PBS-1086. All five containers exhibit go

Synthesis of anthracyclinone precursor: 5,12-dihydroxy-1,3,4- trihydronaphthacene-2,6,11-quinone

Two practical and efficient approaches for preparing large quantities of 5,12-dihydroxy-1,3,4-trihydronaphthacene-2,6,11-quinone 9 are described. Both synthetic approaches involve a simple route with a fewer number of steps and utilize readily available and inexpensive starting materials. Large-scale production of this precursor may prove to be useful for further research involving the synthesis of antineoplastic anthracyclines and development of their analogs with increased activity and decreased toxicity.

Methylidenecycloproparenes: Novel Compounds with Fascinating Properties

Proton abstraction from the methylene position of a cycloproparene provides the corresponding C1 anion that can be intercepted by a carbonyl-containing compound to provide a wide range of novel methylidenecycloproparenes. The physical and chemical aspects of this comparatively new class of surprisingly stable, strained compounds have been explored. The present account provides a perspective on these developments from the initial experiments in the Utah laboratories.

Studies in the cycloproparene series: Oxygen-containing 1H-cyclopropa[b]naphthalenes and their methylidene derivatives

3,6-Dimethoxy-1H-cyclopropa[b]naphthalene 4 is available from 1,4-benzoquinone in four steps in 27-28% overall yield. The diether 4 provides a range of methylidene derivatives 15a-e by way of the disilyl compound 14, and is efficiently demethylated by cerium(IV) ammonium nitrate to provide 1H-cyclopropa[b]naphthalene-3,6-dione 16 (85%) whose crystal structure is reported. Quinone 16 is the first stable cyclopropaquinone but it resists conversion into a 1-C exocyclic olefin. The chemistry of the compounds is described, their spectral data are discussed, and the cyclic voltammetry of 16 is provided.

Construction of a tube-like molecule via sequential cyclopropylidene dimerisation and intramolecular [π2s+π2s] cycloaddition reactions

The syn-cyclopropylidene dimer 5, obtained by reaction of compound 4 with methyllithium, is readily elaborated to the bis-p-benzoquinone 7 which undergoes intramolecular [π2s+π2s] cycloaddition to give the tube-like molecule 8.

Certain tetrahydronaphthalenes used in the treatment of cardiac arrhythmia

Tetrahydronaphthalenes having the structure SPC1And the pharmaceutically acceptable salts thereof, are useful as beta-adrenergic receptor blocking agents in the treatment of cardiac arrhythmia. In the above formula R 1 can be alkyl or arylalkyl and R 2 and R 3 can each be hydrogen, hydroxyl, alkoxy, or arylalkoxy. Those compounds wherein R 1 is arylalkyl and at least one of R 2 and R 3 is other than hydrogen are novel, and constitute a part of this invention.