6272-16-8Relevant academic research and scientific papers
Versatile synthesis of 4-spiro-β-lactam-3-carbonitriles via the intramolecular nucleophilic cyclization of N-(p-hydroxyphenyl)cyanoacetamides
Abdellaoui, Hassane,Xu, Jiaxi
, p. 4323 - 4330 (2014/06/10)
A series of 4-spiro-cyclohexadienonyl-β-lactam-3-carbonitriles, 2,7-dioxo-1-azaspiro[3.5]nona-5,8-diene-3-carbonitriles, was synthesized in satisfactory to excellent yields via the intramolecular nucleophilic cyclization of N-(p-hydroxyphenyl)cyanoacetamides with iodobenzene diacetate (IBD) as oxidant and potassium hydroxide as base. Acetic 4-spiro-cyclohexadienonyl- β-lactam-3-carbimidic anhydrides were obtained when organic base triethylamine was applied instead of potassium hydroxide. The mechanisms of the intramolecular nucleophilic cyclization and formation of acetic β-lactam-3-carbimidic anhydrides were proposed. The cyclization is a sequence of nucleophilic ipso addition and oxidative dearomatization. The formation of acetic carbimidic anhydrides is an acid-catalyzed acetate addition to the nitriles.
Spectral investigation of the activities of amino substituted bases
Ashraf, Muhammad Aqeel,Wajid, Abdul,Mahmood, Karamat,Maah, Mohd. Jamil,Yusoff, Ismail
experimental part, p. 363 - 372 (2012/04/04)
Three new series of biologically active amino substituted Schiff bases with general formula, R1N=CHR2. Here R1 = 2-amino-benzthiazole, 4-amino-salicylic acid and 4-aminophenol. R 2=4-chloro-benzaldehyde, 2-chloro-benzaldehyde, salicylaldehyde, vanillin and benzaldehyde were synthesized by the reaction of three different amino substituted compounds and substituted aldehydes in ethanol. Such compounds were characterized by different physico-chemical techniques like, melting point, elemental analysis, multinuclear nmr (1H, 13C). The free ligands and their metal complexes have been screened for their in vitro biological activities against bacteria, fungi and yeast. The metal complexes show more potent activities compared with Schiff base ligands.
Synthesis, spectral investigation (1H, 13C) of new (N, O and S based) schiff bases and evaluation of their antimicrobial activities
Khosa, Muhammad Kaleem,Chatha, Shahzad Ali Shahid,Nisar, Madhia,Zia, Khalid Mahmood,Khalil-Ur-Rehman,Jamal, Muhammad Asghar,Yousaf, Muhammad
experimental part, p. 421 - 425 (2012/04/17)
Three new series of biologically active amino substituted Schiff bases (1-12) with general formula, R1N=CHR2 (R1 = 2-amino-benzthiazole, 4-amino-salicylic acid and 4-aminophenol; R2 = benzaldehyde, 2-chloro-benzaldehyde, 4-chloro-benzaldehyde, salicylaldehyde and vanillin) were synthesized by the reaction of three different amino substituted compounds and substituted aldehydes in ethanol. The synthesized compounds were characterized by different physico-chemical techniques like, melting point, elemental analysis, multinuclear nmr (1H, 13C). The compounds were subjected for bioassay screening and showed promising antibacterial and antifungal activities using Amoxicillin and Ciprofloxacin as standard drugs.
Evaluation of antibacterial activity of some Schiff bases
Baluja, Shipra,Parikh, Jigna,Chanda, Sumitra,Vaishnani
experimental part, p. 1338 - 1342 (2010/08/05)
From 4-amino phenol, some Schiff bases were synthesized. By IR and NMR spectral data, the structural characterization of these synthesized compounds were done. The antibacterial activity of all these synthesized Schiff bases was studied against B. cereus-ATCC 11778, P. aero-ATCC 27853, E. coli-ATCC 25922, K pneu-NCIM 2719 and 5. aureus-ATCC 25923, by agar ditch method in dimethyl formamide and dimethyl sulfoxide. It is observed that antibacterial activity depends on the molecular structure of Schiff base, solvent used and bacterial strain under consideration. Out of two solvents studied, dimethyl formamide is proved to be best and salicylaldehyde as side chain to 4-amino phenol could be used as lead molecule in drug designing i.e. in inhibiting above bacterial strains.
Preparation and characterization of chromophor group containing cyclotriphosphazenes: I imino chromophor carrying some cyclotriphosphazenes
Odabasoglu, Mustafa,Turgut, Guenseli,Karaer, Hatice
, p. 9 - 25 (2007/10/03)
Some new substituted cyclotriphosphazenes were prepared by the reaction of hexachlorocyclotriphophazene and 4-hydroxy or 4′-hydroxy Schiff bases as 4′-hydroxybenzylideneaniline, 4′-hydroxy-4-chlorobenzylideneaniline, 4′-hydroxy-2-chlorobenzylidenaniline, 4′-hydroxyfurfurylidenaniline, 4-hydroxybenzylidene-2′-methylaniline, 4-hydroxybenzylidene-2′,6′-dimethylaniline, 4-hydroxybenzylidene-2′-chloroaniline, 4-hydroxybenzylidene-4′-tert-butylaniline, 4′-hydroxybenzylidene-3,4-15-Crown-5-aniline. The structure of compounds with a general formula [NP(OC6H4CH=N-Ar)2]3, or [NP(OC6H4N=CH-Ar)2]3, was determined by IR, UV, 1H-NMR and elemental analysis. IR spectra of all compounds showed four characteristic bands located at 1633-1601cm-1, 1242-1150cm-1, 1278-1261cm-1 and 958-943cm-1, respectively, corresponding to CH=N, P=N, P-N-P (asymmetric) and P-N-P (symmetric) vibrations. Charasterictic UV bands, named as Band I, Band II, Band III and Band IV located at 346-308nm, 294-271nm, 262-216nm and 240-210nm respectively, are due to electronic transitions. The 1H-NMR spectra of 4-hydroxyfurfurylidene and the phosphazene derivative shows cis-trans izomerization below 305°K and 295°K.
