62735-66-4Relevant academic research and scientific papers
A Passerini/Michael Pathway towards Butyrolactones
Jia, Shuanglong,El Ka?m, Laurent
, p. 6457 - 6464 (2018/12/04)
The Passerini adducts of aromatic aldehydes may act as nucleophiles in Michael additions with acrylonitrile. The reaction proceeds together with hydrolysis of the ester. The resulting γ-hydroxynitrile may be cyclized under acidic conditions to afford a three-steps synthesis of γ-butyrolactones from isocyanides.
Direct preparation of unsymmetrical difunctionalized cyclen derivatives by an ugi multicomponent reaction
Piersanti, Giovanni,Remi, Francesco,Fusi, Vieri,Formica, Mauro,Giorgi, Luca,Zappia, Giovanni
supporting information; experimental part, p. 417 - 420 (2009/07/18)
(Chemical Equation Presented) A new and efficient synthetic protocol for the preparation of unsymmetrical difunctionalized cyclen and its close derivatives using a modified Ugi reaction (N-split Ugi) is described. The scope of this methodology is further
