627535-23-3Relevant academic research and scientific papers
Oral Bioavailability of a New Class of μ-Opioid Receptor Agonists Containing 3,6-Bis[Dmt-NH(CH2)n]-2(1H)-pyrazinone with Central-Mediated Analgesia
Jinsmaa, Yunden,Miyazaki, Anna,Fujita, Yoshio,Li, Tingyou,Fujisawa, Yutaka,Shiotani, Kimitaka,Tsuda, Yuko,Yokoi, Toshio,Ambo, Akihiro,Sasaki, Yusuke,Bryant, Sharon D.,Lazarus, Lawrence H.,Okada, Yoshio
, p. 2599 - 2610 (2007/10/03)
The inability of opioid peptides to be transported through epithelial membranes in the gastrointestinal tract and pass the blood-brain barrier limits their effectiveness for oral application in an antinociceptive treatment regime. To overcome this limitat
