6276-11-5

Basic information

• Product Name: ethyl N-pyridin-3-ylcarbamate
• Synonyms: ethyl N-pyridin-3-ylcarbamate
• CAS NO: 6276-11-5
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.1772
• Mol File: 6276-11-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 228.5°C at 760 mmHg
• Flash Point: 92°C
• Appearance: /
• Density: 1.198g/cm³
• Vapor Pressure: 0.0731mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: ethyl N-pyridin-3-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl N-pyridin-3-ylcarbamate(6276-11-5)
• EPA Substance Registry System: ethyl N-pyridin-3-ylcarbamate(6276-11-5)

Safety Data

• Hazardous Substances Data: 6276-11-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H10N2O2/c1-2-12-8(11)10-7-4-3-5-9-6-7/h3-6H,2H2,1H3,(H,10,11)

Upstream product

• 462-08-8 pyridin-3-ylamine 
• 541-41-3 chloroformic acid ethyl ester 
• 4013-72-3 nicotinoyl azide 
• 64-17-5 ethanol 
• 141-52-6 sodium ethanolate 
• 98-92-0 nicotinamide 
• 22236-96-0 3-N-formylaminopyridine 

Downstream Products

• 452-58-4 2,3-Diaminopyridine 
• 32605-06-4 3-(N-methylamino)-2-nitropyridine 
• 13269-19-7 3-amino-2-nitropyridine 
• 462-08-8 pyridin-3-ylamine 
• 55304-91-1 ethyl N-(2-nitro-3-pyridyl)carbamate 

Relevant articles and documents

Efficient synthesis of methyl carbamate via Hofmann rearrangement in the presence of TsNBr2

An efficient method has been developed for the synthesis of carbamates from the corresponding amides via the Hofmann rearrangement using N,N-dibromo-p-toluenesulfonamide (TsNBr2) in the presence of DBU in methanol. The reaction goes into completion in 10-20 min at 65 °C to produce the corresponding carbamate in excellent yield.

METHOD FOR OPTICAL RESOLUTION OF ALKYLPIPERIDIN-3-YL CARBAMATE AND INTERMEDIATE THEREFOR

Disclosed is a method for optical resolution of an alkylpiperidin-3-yl carbamate, the method including bringing an RS mixture of an alkylpiperidin-3-yl carbamate into contact with an optically active tartaric acid in the presence of a solvent.

Synthetic Approaches to some Aza-analogues of Benzimidazole N-Oxides. Part 1. The Imidazopyridine Series

The 3-oxide of 2-p-nitrophenylimidazopyridine (8) may be obtained in good yield by base-induced cyclisation of 2-nitro-3-(p-nitrobenzylamino)pyridine (18).It is also obtained in lower yield, along with p-nitrobenzoic acid and other cleavage products, by the corresponding reactions of bases with the N-ethoxycarbonyl, N-methylsulphonyl, and N-p-tolylsulphonyl derivatives of 2-nitro-3-(p-nitrobenzylamino)pyridine .Cleavage is the main reaction when N-(2-nitro-3-pyridyl)-N-phenacylmethanesulphonamide (17) is treated with bases: phenylglyoxal, or its Schiff base with 3-amino-2-nitropyridine, are possible intermediates in the cleavage process. 3-Nitro-2-(p-nitrobenzylamino)pyridine (31) is similarly cyclised in basic media to give the 1-oxide of 2-p-nitrophenylimidazopyridine (32).