6277-60-7

Usage

Uses

Used in Agriculture and Horticulture:
NAA is utilized as a growth stimulant for promoting root formation in cuttings, enhancing fruit setting in fruit trees, and preventing the premature dropping of fruit. Its application helps increase the overall yield and quality of a wide range of crops.
Used in Herbicide and Insecticide Production:
NAA is also employed in the development of herbicides and insecticides, where it leverages its plant growth-regulating properties to control or manage unwanted plant and insect populations.
The application of NAA is typically in the form of a foliar spray or a soak for cuttings, allowing for effective delivery and absorption by the plants. Its versatility and efficacy make it a valuable tool in modern agricultural practices.

InChI:InChI=1/C14H13NO3/c16-13(15-9-14(17)18)8-11-6-3-5-10-4-1-2-7-12(10)11/h1-7H,8-9H2,(H,15,16)(H,17,18)/p-1

Upstream product

• 5121-00-6 naphthalen-1-yl-acetyl chloride 
• 56-40-6 glycine 
• 86-87-3 naphth-1-yl acetic acid 

Relevant academic research and scientific papers

Protection of primary dopaminergic midbrain neurons by GPR139 agonists supports different mechanisms of MPP+ and rotenone toxicity

The G-protein coupled receptor 139 (GPR139) is expressed specifically in the brain in areas of relevance for motor control. GPR139 function and signal transduction pathways are elusive, and results in the literature are even contradictory. Here, we examined the potential neuroprotective effect of GPR139 agonism in primary culture models of dopaminergic (DA) neuronal degeneration. We find that in vitro GPR139 agonists protected primary mesencephalic DA neurons against 1-methyl-4-phenylpyridinium (MPP+)-mediated degeneration. Protection was concentration-dependent and could be blocked by a GPR139 antagonist. However, the protection of DA neurons was not found against rotenone or 6-hydroxydopamine (6-OHDA) mediated degeneration. Our results support differential mechanisms of toxicity for those substances commonly used in Parkinson’s disease (PD) models and potential for GPR139 agonists in neuroprotection.