60962-92-7Relevant academic research and scientific papers
SUBSTITUTED TRIAZINONES AS THYROID HORMONE RECEPTOR AGONISTS
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Paragraph 00188-00189, (2021/07/24)
The application relates to a compound of Formula (I') or (I), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of thyroid hormone receptors, a pharmaceutical composition comprising a compound of Formula (I') or (I), and a method of treating or preventing a disease or disorder regulated by thyroid hormone.
Compound as well as synthesis method and application thereof
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Paragraph 0101; 0106; 0108-0111, (2018/12/02)
The invention provides a compound. The compound is characterized by comprising a structure shown in the description. The novel small-molecule compound can be used for promoting regrowth of hair when applied for external use, and can be used for treating a
A small molecular compound and its synthetic method and application
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Paragraph 0100; 0106; 0108-0110, (2016/12/12)
Provided is a small molecule compound as represented by structural formula (I). The product of the present invention in various concentrations and dosages can achieve an obvious change in the growth period of hairs, promoting the growth of the hairs, thus
Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa
Kitamura, Seiya,Hvorecny, Kelli L.,Niu, Jun,Hammock, Bruce D.,Madden, Dean R.,Morisseau, Christophe
supporting information, p. 4790 - 4799 (2016/06/13)
The virulence factor cystic fibrosis transmembrane conductance regulator (CFTR) inhibitory factor (Cif) is secreted by Pseudomonas aeruginosa and is the founding member of a distinct class of epoxide hydrolases (EHs) that triggers the catalysis-dependent
Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor β (TR-β) selective ligands
Raval, Saurin,Raval, Preeti,Bandyopadhyay, Debdutta,Soni, Krunal,Yevale, Digambar,Jogiya, Digvijay,Modi, Honey,Joharapurkar, Amit,Gandhi, Neha,Jain, Mukul R.,Patel, Pankaj R.
scheme or table, p. 3919 - 3924 (2009/04/07)
Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay. The 3-[3,5-dichloro-4-(4-hydroxy-3-isopropylph
Synthesis and Structure-Activity Relationships of Oxamic Acid and Acetic Acid Derivatives Related to L-Thyronine
Yokoyama, Naokata,Walker, Gordon N.,Main, Alan J.,Stanton, James L.,Morrissey, Michael M.,et al.
, p. 695 - 707 (2007/10/02)
Aryloxamic acids 7 and 23, (arylamino)acetic acids 29, arylpropionic acids 33, arylthioacetic acids 37, and (aryloxy)acetic acid 41 related to L-triiodothyronine (L-T3) were prepared and tested in vitro for binding to the rat liver nuclear L-T
