62780-67-0

Usage

Uses

Used in Cardiology:
Amiodarone is utilized as an antiarrhythmic agent for the treatment of both ventricular and supraventricular arrhythmias. Its long half-life and ability to stabilize heart rhythm make it a valuable asset in managing these conditions.
However, due to its complex pharmacokinetics and potential for serious side effects, such as pulmonary toxicity, thyroid dysfunction, and liver toxicity, amiodarone requires close monitoring and careful dosing by healthcare professionals to ensure its safe and effective use in patients.

InChI:InChI=1/C9H10Cl2N2O3/c10-6-4-8(12-2-1-3-14)9(13(15)16)5-7(6)11/h4-5,12,14H,1-3H2

Upstream product

• 89-69-0 2,4,5-Trichloronitrobenzene 
• 156-87-6 propan-1-ol-3-amine 
• 67-66-3 chloroform 
• 2339-78-8 1,2-dichloro-4-fluoro-5-nitrobenzene 

Relevant academic research and scientific papers

Discovery of a novel B-cell lymphoma 6 (BCL6)–corepressor interaction inhibitor by utilizing structure-based drug design

B-cell lymphoma 6 (BCL6) is a transcriptional repressor that can form complexes with corepressors via protein–protein interactions (PPIs). The complexes of BCL6 and corepressors play an important role in the formation of germinal centers (GCs), and differentiation and proliferation of lymphocytes. Therefore, BCL6–corepressor interaction inhibitors would be drug candidates for managing autoimmune diseases and cancer. Starting from high-throughput screening hits 1a and 2a, we identified a novel BCL6–corepressor interaction inhibitor 8c (cell-free enzyme-linked immunosorbent assay [ELISA] IC50 = 0.10 μM, cell-based mammalian two-hybrid [M2H] assay IC50 = 0.72 μM) by utilizing structure-based drug design (SBDD) based on an X-ray crystal structure of 1a bound to BCL6. Compound 8c also showed a good pharmacokinetic profile, which was acceptable for both in vitro and in vivo studies.

1-[(Heterocyclyl)-alkyl]-4-diarylmethoxy piperidine derivatives

Novel 1-[(heterocyclyl)alkyl]-4-diarylmethoxy piperidine derivatives are disclosed having the formula STR1 where n is 2-6, Ar1 and Ar2 are aryl and B is a substituted benzimidazolyl radical. These compounds are useful for their antianaphylactic and antihistaminic properties. Specific claimed compounds are 1-{3-[4-(diphenylmethoxy)-1-piperidinyl]-propyl}-1,3-dihydro-2H-benzimidazol-2-one, 1-{2-[4-(diphenylmethoxy)-1-piperidinyl]ethyl}1-, 3-dihydro-2H-benzimidazol-2-one, and 1-{4-[4-(diphenylmethoxy)-1-piperidinyl]butyl}-1,3-dihydro-2H-benzimidazol-2-one.

1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds

Compounds of the class of 1-(benzazolyalkyl)piperidine derivatives useful as antiemetic agents.

1-Benzazolylalkyl-4-substituted-piperidines

Compounds of the class of 1-(benzazolyalkyl)piperidine derivatives, useful as neuroleptic agents.