62790-85-6Relevant articles and documents
Synthesis of N-benzyl substituted 1,4-imino-L-lyxitols with a basic functional group as selective inhibitors of Golgi α-mannosidase IIb
Klunda, Tomá?,?esták, Sergej,Kóňa, Juraj,Poláková, Monika
, p. 424 - 431 (2019)
Inhibition of the biosynthesis of complex N-glycans in the Golgi apparatus is one of alternative ways to suppress growth of tumor tissue. Eight N-benzyl substituted 1,4-imino-L-lyxitols with basic functional groups (amine, amidine, guanidine), hydroxyl an
Silicon-Free SuFEx Reactions of Sulfonimidoyl Fluorides: Scope, Enantioselectivity, and Mechanism
Baggerman, Jacob,Jordaan, Daan,Liang, Dong-Dong,Streefkerk, Dieuwertje E.,Wagemakers, Jorden,Zuilhof, Han
supporting information, p. 7494 - 7500 (2020/03/23)
SuFEx reactions, in which an S?F moiety reacts with a silyl-protected phenol, have been developed as powerful click reactions. In the current paper we open up the potential of SuFEx reactions as enantioselective reactions, analyze the role of Si and outline the mechanism of this reaction. As a result, fast, high-yielding, “Si-free” and enantiospecific SuFEx reactions of sulfonimidoyl fluorides have been developed, and their mechanism shown, by both experimental and theoretical methods, to yield chiral products.
Discovery of Novel N-(4-Hydroxybenzyl)valine Hemoglobin Adducts in Human Blood
Degner, Amanda,Carlsson, Henrik,Karlsson, Isabella,Eriksson, Johan,Pujari, Suresh S.,Tretyakova, Natalia Y.,T?rnqvist, Margareta
, p. 1305 - 1314 (2018/12/11)
Humans are exposed to a wide range of electrophilic compounds present in our diet and environment or formed endogenously as part of normal physiological processes. These electrophiles can modify nucleophilic sites of proteins and DNA to form covalent addu
