6280-47-3

Usage

General Description

4-[2-(4-chlorophenyl)ethenyl]phenol is a chemical compound with a molecular formula C16H12ClO. It is a derivative of resveratrol, a polyphenolic compound found in grapes and various plants. This chemical is often used in the production of cosmetics, personal care products, and dietary supplements due to its antioxidant and anti-inflammatory properties. It is also being studied for its potential applications in medical research and drug development. The presence of a chlorophenyl group in its structure gives it the ability to act as an inhibitor of certain enzymes and receptors, making it a valuable compound in various fields of research and product development.

Upstream product

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Relevant academic research and scientific papers

Searching for new tools to counteract the helicobacter pylori resistance: The positive action of resveratrol derivatives

The drug-resistance phenomenon in Helicobacter pylori underlines the need of novel strategies to improve the eradication rate including alternative treatments combining antibiotic and non-antibiotic compounds with synergistic action. In this study, the antibacterial (MIC/MBC) and anti-virulence effects (biofilm reduction and swarming motility inhibition) of resveratrol-RSV and new synthetized RSV-phenol derivatives, with a higher bioavailability, alone and combined with levofloxacin-LVX were evaluated against resistant H. pylori clinical strains. The experiments were confirmed in vivo using the Galleria mellonella model. Among the studied RSV derivatives, RSV-3 and RSV-4 possessed higher antibacterial activity with respect to RSV (MICs from 6.25 to 200 μg/mL and from 3.12 to 200 μg/mL, respectively). RSV, RSV-3, and RSV-4 were able to synergize with LVX restoring its effect in two out of seven clinical resistant strains tested for the study. RSV, RSV-3, and RSV-4, alone and with LVX at sub-MIC and sub-synergistic concentrations, significantly reduced the biofilm formation. Moreover, RSV-3 and RSV-4 reduced the H. pylori swarming motility on soft agar. RSV, RSV-3, and RSV-4 were non-toxic for G. mellonella larvae and displayed a protective effect against H. pylori infection. Overall, RSV–phenol derivatives should be considered interesting candidates for innovative therapeutic schemes to tackle the H. pylori antibiotic resistance.