6281-58-9 Usage
Uses
Used in Pharmaceutical Industry:
4-(2-methyl-1-pyrrolidyl)-7-chloroquinoline is used as an antimalarial drug for the treatment of malaria and multidrug-resistant (MDR) strains. It works by inhibiting the growth and reproduction of Plasmodium parasites, which are responsible for causing malaria. Chloroquine's ability to accumulate in the food vacuoles of the parasites and raise the pH, thereby disrupting the digestion of hemoglobin, makes it an effective treatment option.
Additionally, Chloroquine has been explored for its potential use in other applications, such as the treatment of autoimmune diseases like lupus and rheumatoid arthritis, due to its immunomodulatory and anti-inflammatory effects. However, it is important to note that the use of Chloroquine for these purposes is still under investigation and not yet widely accepted as a standard treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 6281-58-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,2,8 and 1 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 6281-58:
(6*6)+(5*2)+(4*8)+(3*1)+(2*5)+(1*8)=99
99 % 10 = 9
So 6281-58-9 is a valid CAS Registry Number.
InChI:InChI=1/C14H15ClN2/c1-10-3-2-8-17(10)14-6-7-16-13-9-11(15)4-5-12(13)14/h4-7,9-10H,2-3,8H2,1H3
6281-58-9Relevant academic research and scientific papers
A convenient, short synthesis of desethylchloroquine [7-chloro-4-(4'-ethylamino-1'-methylbutylamino)quinoline]
Ansari,Craig
, p. 147 - 149 (2007/10/02)
A short, efficient 2-step synthesis of desethylchloroquine is achieved by generating an internal amide ion from the secondary nitrogen in chloroquine, followed by in situ reaction with 2,2,2-trichloroethyl chloroformate giving rapid elimination of ethylene. The carbamate thus produced easily undergoes deprotection to the target compound at room temperature.
