62812-90-2

Upstream product

• 75-15-0 carbon disulfide 
• 123-30-8 4-amino-phenol 
• 121-44-8 triethylamine 

Downstream Products

• 2131-60-4 4-hydroxyphenyl isothiocyanate 
• 61700-59-2 (4-hydroxyphenyl)cyanamide 
• 1520-27-0 1-(4-hydroxyphenyl)thiourea 

Relevant academic research and scientific papers

NIFUROXAZIDE ANALOGS AND THERAPEUTIC USES THEREOF

Nifuroxazide analogs, and their pharmaceutically acceptable salts and derivatives are described. Methods and uses are also provided that include the administration of an effective amount of the nifuroxazide analogs, or their pharmaceutically acceptable sa

First Examples of H2S-Releasing Glycoconjugates: Stereoselective Synthesis and Anticancer Activities

H2S donors are currently emerging as promising therapeutic agents in a wide variety of pathologies, including tumors. Cancer cells are characterized by an enhanced uptake of sugars, such as glucose. Therefore, novel glycoconjugated H2/sub

Na2S2O8-mediated efficient synthesis of isothiocyanates from primary amines in water

We have developed two green, practical, and efficient procedures, including a one-pot one, to synthesize isothiocyanates from amines and carbon disulfide via desulfurization with sodium persulfate. Water is used as the solvent. Basic conditions are necessary for good chemoselectivity for isothiocyanates. Structurally diverse linear and branched alkyl amines and aryl amines are readily converted to isothiocyanates by the two procedures in satisfactory yields. Halogens, benzylic C-H bonds, methylthio, nitro, ester, alkenyl, electron-rich or -deficient (hetero)aryls, acetylenyl, and even phenolic and alcoholic hydroxyls are well tolerated. The one-pot procedure in water can also be used to realize the preparation of chiral isothiocyanates from chiral amines, and the modification of bioactive structures with free amino groups. In large-scale preparation, simple and practical purification procedures independent of column chromatography are developed.

Synthesis and reactivity studies of a new reagent, ethyltriphenylphosphonium tribromide

A new reagent, ethyltriphenyl phosphonium tribromide (ETPPTB), has been synthesized and studied. Results show that the reagent is quite efficient for various reactions such as organic bominations, acylations, and isothiocyanate preparation. Copyright

A one-pot preparation of cyanamide from dithiocarbamate using molecular iodine

An efficient one-pot method for the synthesis of cyanamides from dithiocarbamate salts via a double desulfurization strategy using molecular iodine is disclosed. Dithiocarbamates, by the action of iodine yield isothiocyanates in situ, which on treatment with aqueous NH3 give thioureas. The thioureas so generated undergo further oxidative desulfurization with I2 giving corresponding cyanamides in good yields. Environmental benignity, cost effectiveness and high yields are the important attributes of this one pot procedure. The Royal Society of Chemistry 2009.

Isothiocyanates from tosyl chloride mediated decomposition of in situ generated dithiocarbamic acid salts

(Chemical Equation Presented) A facile and general protocol for the preparation of isothiocyanates from alkyl and aryl amines is reported. This method relies on a tosyl chloride mediated decomposition of a dithiocarbamate salt that is generated in situ by treatment of an amine with carbon disulfide and triethylamine. Utilizing this protocol, we have prepared 19-alkyl- and arylisothiocyanates in moderate to excellent yield.

Insect control compounds

The invention is novel hydrocarbon ethers of aminophenol derivatives, and their use in preventing the proliferation of insects by interfering with their normal development and growth pattern.