628329-63-5Relevant academic research and scientific papers
Novel 1,3-dipropyl-8-(3-benzimidazol-2-yl-methoxy-1-methylpyrazol-5-yl) xanthines as potent and selective A2B adenosine receptor antagonists
Baraldi, Pier Giovanni,Baraldi, Stefania,Saponaro, Giulia,Preti, Delia,Romagnoli, Romeo,Piccagli, Laura,Cavalli, Andrea,Recanatini, Maurizio,Moorman, Allan R.,Zaid, Abdel Naser,Varani, Katia,Borea, Pier Andrea,Tabrizi, Mojgan Aghazadeh
, p. 797 - 811 (2012/03/27)
Molecular modeling studies, including the comparative molecular field analysis (CoMFA) method, on 52 antagonists of the A2B adenosine receptor with known biological activity were performed to identify the three-dimensional features responsible
1,2-AZOLE DERIVATIVES WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY
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, (2010/02/05)
A compound represented by the formula (1) wherein ring A is a ring optionally having 1 to 3 substituents; ring B is a 1,2-azole ring which may further have 1 to 3 substituents; Xa, Xb and Xc are the same or different and each is a bond, - O -, - S - and the like; Ya is a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; Yb and Yc are the same or different and each is a bond or a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; ring C is a monocyclic aromatic ring which may further have 1 to 3 substituents; and R represents -OR4 (R4 is hydrogen atom or optionally substituted hydrocarbon group) and the like, or a salt thereof or a prodrug thereof is useful as an agent for the prophylaxis or treatment of diabetes and the like.
