62848-99-1Relevant academic research and scientific papers
On the synthesis of arylpropiolic acids and investigations towards the formation of vinyl chlorides by HCl addition during esterification reactions
Hapke, Marko,Kral, Karolin,Spannenberg, Anke
experimental part, p. 642 - 652 (2011/04/15)
The synthesis protocol for the preparation of different arylpropiolic acids using the Negishi reaction and the addition of HCl to the alkyne moiety of these acids in subsequent esterification reactions using SOCl2 was examined. Georg Thieme Verlag Stuttgart New York.
2,5-diarylisothiazolone: Novel inhibitors of cytokine-induced cartilage destruction
Wright, Stephen W.,Petraitis, Joseph J.,Freimark, Bruce,Giannaras, John V.,Pratta, Michael A.,Sherk, Susan R.,Williams, Jean M.,Magolda, Ronald L.,Arner, Elizabeth C.
, p. 851 - 858 (2007/10/03)
A series of 2,5-diarylisothiazolones is reported that inhibit the IL-1β- induced breakdown of bovine nasal septum cartilage in an organ culture assay. The synthesis and preliminary SAR of these compounds are described. These compounds represent a novel, n
Flash Vacuum Pyrolysis of Stabilised Phosphorous Ylides. Part 4. Stepwise Construction of Terminal 1,3-Diynes, Conjugated Diacetylenic Esters and a Triacetylenic Ester
Aitken, R. Alan,Seth, Shirley
, p. 2461 - 2466 (2007/10/02)
Thirteen examples of stabilised alkynol ylides 6 have been prepared and are found, upon flash vacuum pyrolysis (FVP) at 500 deg C, to undergo extrusion of Ph3PO to give the diacetylenic esters 7 in moderate yield.At 750 deg C the same ylides afforded terminal 1,3-diynes 8 although often in poor yield.For R = 2-MeSC6H4 both 7 and 8 undergo secondary loss of Me* and cyclisation to give 2-alkynylbenzothiophene derivatives 9 and 10 in low yield.The first example of an alkadiynol ylide 11 has been prepared and is converted by FVP at 500 deg C into the triacetylenic ester 12.
