6286-49-3

Usage

Structure

Contains a benzene ring with two methoxy groups (-OCH3) attached to the 3 and 4 positions, and two nitrile groups (-C≡N) attached to a butane chain.

Type of compound

A chemical compound that is a nitrile derivative of 3,4-dimethoxybenzophenone.

Uses

Commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals.

Reactivity

Unique reactivity and properties due to the presence of two nitrile groups and two methoxy groups on the benzene ring.

Applications

Mainly used in organic synthesis and found in various research and development applications.

Handling precautions

Potential hazards and reactivity should be considered, and the compound should be handled with care.

Upstream product

• 24393-47-3 ethyl (E)-2-cyano-3-(3,4-dimethoxyphenyl)-2-propenoate 
• 143-33-9 sodium cyanide 
• 773837-37-9 sodium cyanide 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 2286-55-7 ethyl α-cyano-β-(3,4-dimethoxyphenyl)acrylate 

Downstream Products

• 153718-53-7 1-acetamido-4-amino-2-(3,4-dimethoxyphenyl)butane 
• 94357-78-5 3-(3,4-dimethoxyphenyl)-1-n-propylpyrrolidine 
• 94357-77-4 2-(3,4-dimethoxyphenyl)-N-(n-propyl)succinimide 
• 94357-76-3 3-(3,4-dimethoxyphenyl)pyrrolidine-2,5-dione 
• 38175-31-4 (+/-)-3-(3,4-dimethoxyphenyl)pyrrolidine 
• 153718-52-6 4-acetamido-3-(3,4-dimethoxyphenyl)butyronitrile 

Relevant academic research and scientific papers

Ring Opening of Donor-Acceptor Cyclopropanes with Cyanide Ion and Its Surrogates

A straightforward method for ring opening of donor-acceptor cyclopropanes with trimethylsilyl cyanide as a surrogate of cyanide ion in the presence of B(C6F5)3 or trifluoromethanesulfonic acid as a catalyst has been developed. The methodology provides a short route to γ-cyanoesters that can be useful synthetic intermediates for the synthesis of diverse bioactive molecules such as glutaric and δ-aminovaleric acid derivatives, 3-arylpiperidines, or other substituted phenethylamines. Oppositely, the attempts to synthesize these γ-cyanoesters by direct reaction of cyclopropanes with sodium cyanide under typical SN2 conditions led to the formation of 2-arylsuccinonitriles.

Synthetic studies of the pyrroloquinoline nucleus of the makaluvamine alkaloids. Synthesis of the topoisomerase II inhibitor makaluvamine D

A new synthesis of the pyrrolo[4,3,2-de]quinoline system characteristic of a class of marine alkaloids which includes the prianosins, discorhabdins, and other antineoplastic agents has been developed. The approach is exemplified in a total synthesis of ma

Synthesis and dopaminergic activity of 3-(3,4-dihydroxyphenyl)-1-n-propylpyrrolidine hydrobromide

3-(3,4-Dihydroxyphenyl)-1-n-propylpyrrolidine hydrobromide was synthesized by a six-step reaction sequence and was evaluated, and compared with apomarphine, for central dopaminergic agonist activity. The compound produced behavioral and biochemical change