6287-66-7

Upstream product

• 141-97-9 ethyl acetoacetate 
• 94-41-7 benzalacetophenone 
• 85156-98-5 ethyl 4-hydroxy-2-oxo-4,6-diphenylcyclohexanecarboxylate 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 65043-08-5 ethyl 4-diethoxyphosphoryl-3-oxobutanoate 
• 100-52-7 benzaldehyde 
• 98-86-2 acetophenone 
• 15802-62-7 (Z)-ethyl 2-benzylidenacetoacetate 

Downstream Products

• 127143-07-1 ethyl 1-(2-cyanoethyl)-2-oxo-4,6-diphenyl-3-cyclohexene-1-carboxylate 
• 14164-76-2 3,5-diphenyl-6-methyl-2-cyclohexen-1-one 
• 33733-05-0 1,5-Diphenyl-4-methylcyclohexan-3-ol 
• 33733-06-1 1-Methylen-3,5-diphenylcyclohex-2-en 
• 1290639-93-8 7,9-diphenyl-1,4-diazaspiro[4.5]deca-9-ene-6-ethyl carboxylate 
• 138841-02-8 2-Acetoxy-4,6-diphenyl-cyclohexa-1,3-dienecarboxylic acid ethyl ester 
• 14164-75-1 6-Carbethoxy-3.5-diphenyl-6-methyl-2-cyclohexen-1-on 

Relevant academic research and scientific papers

Base-promoted reactions in ionic liquid solvents. The Knoevenagel and Robinson annulation reactions

When used in place of classical organic solvents, ionic liquids offer a new and environmentally benign approach toward solvation in modern synthetic chemistry. Two classical named reactions, the Knoevenagel condensation and Robinson annulation, have been

One-pot insertion of chalcones into the benzoylacetone backbone

Interaction of 1-phenylbutane-1,3-dione and chalcones in the presence of a base gives, in one step, good to high yields cyclic and unusual acyclic insertion products in ratios which depend on substrate, catalyst, and reaction conditions. All the synthesiz

Nylon monomer and preparation method thereof

The invention provides four nylon monomers and a preparation method thereof, wherein a nylon monomer is formed at 3 positions and 5 positions of a lactam or pimelic acid, and a preparation method of the nylon monomer is used for chalcone. The ethyl acetoa

Metal-Free I2-Catalyzed Highly Selective Dehydrogenative Coupling of Alcohols and Cyclohexenones

The I2 catalyzed highly selective oxidative condensation of cyclohexenones and alcohols for the synthesis of aryl alkyl ethers has been described. DMSO is employed as the mild terminal oxidant. This novel methodology offers a metal-free reaction condition, operational simplicity and broad substrate scope to afford valuable products from inexpensive reagents. Various meta-substituted aromatic ethers which are hardly synthesized from the reported methods requiring meta-substituted phenols, are efficiently prepared by the present protocol.

Conversion of Simple Cyclohexanones into Catechols

A novel I2-catalyzed direct conversion of cyclohexanones to substituted catechols under mild and simple conditions has been described. This novel transformation is remarkable with the multiple oxygenation and dehydrogenative aromatization processes enabled just by using DMSO as the solvent, oxidant, and oxygen source. This metal-free and simple system demonstrates a versatile protocol for the synthesis of highly valuable substituted catechols and therefore streamlines the synthesis and modification of biologically important molecules for drug discovery.

A highly efficient metal-free approach to: Meta - And multiple-substituted phenols via a simple oxidation of cyclohexenones

A novel and efficient metal-free approach to substituted phenols has been disclosed from simple and readily available cyclohexenones and cyclohexenone equivalents. Dimethyl sulfoxide (DMSO), a simple and common organic reagent, was employed as a mild oxidant in this I2-catalysis, which significantly tolerates various substituents including some easily oxidizable or reducible functionalities. The challenging meta- and multiple-substituted phenols could be well prepared by this method. The metal-free and mild oxidation make this protocol very simple, practical, and easy to handle.

Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives

Novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives were synthesized and characterized by using spectral techniques like IR, 1H NMR, 13C NMR, COSY, DEPT, and GC-MS. All these compounds were screened for anti-fungal, anti-bacterial and anti-oxidant activity. Cyclohexenone derivatives, in general, showed better anti-fungal and anti-bacterial activity than parent chalcones. Whereas, all the Indazole derivatives showed very good anti-oxidant activity and some were also found to be active as anti-bacterial agent. Among the screened compounds, 15 was found to be most active as anti-fungal agent (against Rhizoctonia solani, LC 50 = 2.36 μg mL-1), 15b was found to be most active anti-bacterial agent (against Klebsiella pneumonia, MIC = 24.68 μg mL -1) and 14b emerged as most active anti-oxidant (IC50 = 19.81 μg mL-1).

Activated fly ash catalyzed facile synthesis of novel spiro imidazolidine derivatives as potential antibacterial and antifungal agents

An array of novel spiro imidazolidine derivatives was synthesized in dry media and was screened for their anti-microbial activities. Structure-activity relationship results revealed that compounds 22, 23 against P.aeruginosa, 24 against S.aureus, 24, 25 against K.pneumonia, 27 against S.aureus, β-H.streptococcus, 29 against M.luteus, K.pneumonia, 29, 30 against P.vulgaris exhibited excellent antibacterial activity at a minimum inhibitory concentration (MIC) value of 6.25 μg/mL. Compound 23 against M.gypseum, 25, 29 against Candida 6 and 29, 30 against C.albicans revealed excellent antifungal activity at a MIC value of 6.25 μg/mL.

Synthesis, spectral analysis, and in vitro microbiological evaluation of ethyl 7,9-diaryl-1, 4-diazaspiro[4.5]dec-9-ene-6-carboxylates as a new class of antibacterial and antifungal agents

A series of novel ethyl 7,9-diaryl-1,4-diazaspiro[4.5]dec-9-ene-6- carboxylates was synthesized by the reaction of ethyl 4,6-diaryl-2-oxocyclohex- 3-ene-1-carboxylates with ethylenediamine in the presence of p-toluenesulfonic acid without a solvent under focused microwave irradiation. The title compounds were screened for their antimicrobial activities against a spectrum of clinically isolated microorganisms.

1H and 13C NMR spectral study of some 3-aryl-5r-aryl-6t-carbethoxycyclohex-2-enones - A study of four-bond 1H-1H couplings

Nine 3-aryl-5r-aryl-6t-carbethoxycyclohex-2-enones 2a-2i have been synthesized. For all these compounds, 1H and 13C NMR spectra have been recorded. For two compounds, 2D spectra have been recorded. The spectral data suggest that thes