62894-04-6

Upstream product

• 65755-94-4 3,3-dimethyl-2-phenyl-2-(trimethylsiloxy)-4-pentenal 
• 98-88-4 benzoyl chloride 
• 503-60-6 3,3-dimethyl-allyl chloride 
• 100-47-0 benzonitrile 
• 870-63-3 prenyl bromide 
• 93-97-0 benzoic acid anhydride 
• 39158-85-5 2-methyl-1-phenyl-1-trimethylsiloxy-1-propene 
• 1066-54-2 trimethylsilylacetylene 
• 100-52-7 benzaldehyde 
• 613-90-1 benzoyl cyanide 
• 27644-02-6 2,2-dimethyl-1-phenylbut-3-en-1-ol 
• 865-58-7 3-bromo-3-methyl-but-1-ene 
• 20633-40-3 methyl 4-benzoyl-4-methylvalerate 
• 2938-68-3 4,4-dimethyl-5-oxo-5-phenylpentanoic acid 

Downstream Products

• 27644-02-6 2,2-dimethyl-1-phenylbut-3-en-1-ol 
• 1221447-21-7 (E)-2,2-dimethyl-1-phenylbut-3-en-1-one oxime 
• 1428236-05-8 4,4,5-trimethyl-3-phenyl-4,5-dihydroisoxazole 

Relevant academic research and scientific papers

New electrochemical preparation of reactive zinc with a large surface area

Reactive zinc was readily prepared by electrolysis of a DMF solution containing 0.1M Et4NClO4 using a platinum cathode and a zinc anode. Characterization of the zinc metal showed that it was an aggregation of very line, crystalline z

Method for synthesizing polysubstituted alpha, beta unsaturated ketones

The invention particularly relates to a method for synthesizing polysubstituted alpha, beta unsaturated ketones. The method comprises the following steps: 1, adding Ni(cod), an N-heterocyclic carbene ligand, Cs2CO3 and a beta, gamma unsaturated ketone into a non-polar aprotic organic solvent, and mixing to obtain a mixture; 2, adding the mixture obtained in the step 1 into a dried container, reacting for 10-40 hours at the reaction temperature of 120-180 DEG C, and cooling to room temperature after the reaction is finished, so as to obtain a crude product; 3, purifying. According to the method, cheap Ni(cod) is adopted as a catalyst, carbon-carbon bonds are activated by a transition metal, power is provided for the reaction through isomerization of double bonds, the synthesis methodis simple, the substrates are stable and cheap, the reaction is less limited by the substrate, and the substrates are wide in application range.

Ni-Catalyzed 1,2-Acyl Migration Reactions Triggered by C-C Bond Activation of Ketones

A Ni-catalyzed 1,2-acyl migration triggered by C-C bond cleavage was developed. The process of 1,2-acyl migration followed by olefin isomerization provides a convenient access to α,β-unsaturated ketones, which are well-known building blocks in organic syn

Trifluoromethylthiolation and trifluoromethanesulfonylation of β,γ-unsaturated hydrazones

The trifluoromethylthiolation and trifluoromethanesulfonylation of β,γ-unsaturated hydrazones was accomplished with silver(I) trifluoromethanethiolate (AgSCF3) as a CF3S source and sodium trifluoromethylsulfinate (CF3SO2Na) as a CF3SO2 source, respectively. These general methods for the preparation of dihydropyrazoles containing CF3S or CF3SO2 groups were characterized by mild reaction conditions and good functional group tolerance.

Copper-Promoted 6- endo-trig Cyclization of β,γ-Unsaturated Hydrazones for the Synthesis of 1,6-Dihydropyridazines

A novel and efficient strategy for the synthesis of 1,6-dihydropyridazines via copper-promoted 6-endo-trig cyclization of readily available β,γ-unsaturated hydrazones have been developed. A series of 1,6-dihydropyridazines have been synthesized by this method with good yields, high functional group tolerance, and remarkable regioselectivity under mild conditions. Importantly, the 1,6-dihydropyridazines can be efficiently converted to biologically important pyridazines in the presence of NaOH.

Copper-Catalyzed Diamination of Alkenes of Unsaturated Ketohydrazones with Amines

A convenient copper-catalyzed intra-/intermolecular diamination of β,γ-unsaturated hydrazones has been developed with simple amines as external amine sources. The protocol enables efficient access to various nitrogen-containing pyrazolines under mild reaction conditions.

Iminoxyl Radical-Promoted Oxycyanation and Aminocyanation of Unactivated Alkenes: Synthesis of Cyano-Featured Isoxazolines and Cyclic Nitrones

A novel and facile approach to vicinal oxycyanation and aminocyanation of internal unactivated alkenes is developed. This method utilizes the dichotomous reactivity of iminoxyl radical derived from the initiation of β,γ- and γ,δ-unsaturated ketoximes to provide the general difunctionalization of internal alkenes using tert-butyl hydroperoxide (TBHP) as the environmentally friendly oxidant, CuCN as the commercially available cyanating reagent, and pentamethyldiethylenetriamine (PMDETA) as the ligand. By using this protocol, a series of useful cyano-featured isoxazolines and cyclic nitrones were efficiently prepared.

Oxime-mediated oxychlorination and oxybromination of unactivated olefins

An oxime-mediated oxychlorination and oxybromination of unactivated olefins relying on palladium catalysis has been developed. A wide range of chlorinated and brominated isoxazolines has been synthesized in moderate to good yields. To demonstrate the value of the method, the brominated isoxazoline has been further converted to other useful synthetic feedstock.

Palladium-Catalyzed Decarbonylative Dehydration for the Synthesis of α-Vinyl Carbonyl Compounds and Total Synthesis of (-)-Aspewentins A, B, and C

The direct α-vinylation of carbonyl compounds to form a quaternary stereocenter is a challenging transformation. It was discovered that δ-oxocarboxylic acids can serve as masked vinyl compounds and be unveiled by palladium-catalyzed decarbonylative dehydr

Copper-catalyzed 5-endo-trig cyclization of ketoxime carboxylates: A facile synthesis of 2-arylpyrroles

A novel and facile copper-catalyzed 5-endo-trig cyclization of ketoxime carboxylates for the synthesis of 2-arylpyrroles has been developed. The reaction tolerates a range of functional groups and is a practical procedure for rapid synthesis of 2-arylpyrroles in high yields under mild conditions. the Partner Organisations 2014.