62894-08-0

Upstream product

• 15963-39-0 Δ²-Cyclobutenyl-methyltosylat 
• 64666-40-6 2-cyclopenten-1-yl 3,5-dinitrobenzoate 
• 359-48-8 trifluoroacetyl peroxide 
• 68241-89-4 [(cyclopent-2-en-1-yloxy)methyl]benzene 
• 58623-66-8 3-chlorocyclopentene 
• 151-50-8 potassium cyanide 
• 16326-97-9 1,3-dihydroxycyclopentane 
• 1755-01-7 endo-Dicyclopentadien 
• 145123-28-0 10,10-Difluorotricyclo<5.2.1.0^2,6>dec-8-en-3-ol 
• 109391-80-2 C₁₁H₁₃Cl₃Se 
• 75-52-5 nitromethane 
• 142-29-0 cyclopentene 
• 96042-30-7 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 
• 930-30-3 cyclopent-2-enone 

Downstream Products

• 64666-40-6 2-cyclopenten-1-yl 3,5-dinitrobenzoate 
• 15131-55-2 di-2-cyclopenten-1-yl ether 
• 52168-74-8 (3aR,4S,6aS)-3-Phenyl-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazol-4-ol 
• 52168-66-8 (3aSR,6RS,6aRS)-3-phenyl-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazol-6-ol 
• 52168-66-8 6-hydroxy-3-phenyl-3α,5,6α,6aα-tetrahydro-4H-cyclopenta[d]isoxazole 
• 1120-62-3 3-methyl-1-cyclopentene 
• 80663-68-9 (2R,3R)-3-Chloro-2-phenylselanyl-cyclopentanol 
• 64145-51-3 3-phenylcyclopentanone 
• 111075-05-9 cyclopent-2-enyl 2,6-dinitrobenzoate 
• 146287-23-2 2-cyclopentenyl diphenylphosphinate 
• 13668-59-2 3-hydroxymethyl-cyclopentene 
• 765-54-8 trans-2,3-epoxycyclopentanol 
• 25484-62-2 cis-6-oxabicyclo<3.1.0>cyclohexan-2-ol 
• 930-30-3 cyclopent-2-enone 

Relevant academic research and scientific papers

Multiple Olefin Metathesis Polymerization That Combines All Three Olefin Metathesis Transformations: Ring-Opening, Ring-Closing, and Cross Metathesis

We demonstrated tandem ring-opening/ring-closing metathesis (RO/RCM) polymerization of monomers containing two cyclopentene moieties and postmodification via insertion polymerization. In this system, well-defined polymers were efficiently formed by tandem cascade RO/RCM reaction pathway. Furthermore, these polymers could be transformed to new A,B-alternating copolymers via a sequential cross metathesis reaction with a diacrylate. Additionally, we demonstrated the concept of multiple olefin metathesis polymerization in which the dicyclopentene and diacrylate monomers underwent all three olefin metathesis transformations (ring-opening, ring-closing, and cross metathesis) in one shot to produce A,B-alternating copolymer.

Cyclopentadiene fuels

A method for making cyclopentadiene fuels comprising producing cyclopent-2-en-1-one or a mixture of cyclopent-2-en-1-one from a bio-based source. The cyclopent-2-en-1-one or the mixture of cyclopent-2-en-1-one is hydrogenated, thereby forming cyclopent-2-en-1-ol or a mixture of cyclopent-2-en-1-ol. The cyclopent-2-en-1-ol or the mixture of cyclopent-2-en-1-ol is dehydrated with a dehydrating agent, thereby forming cyclopentadiene or a mixture of cyclopentadiene. The cyclopentadiene or mixture of cyclopentadiene is converted to dicyclopentadiene or dihydrodicyclopentadiene. The dicyclopentadiene or dihydrodicyclopentadiene is hydrogenated, thereby forming tetrahydrodicyclopentadiene. The tetrahydrodicyclopentadiene is isomerized, thereby forming exo-tetrahydrodicyclopentadiene.

Ruthenium-p-cymene Complex Side-Wall Covalently Bonded to Carbon Nanotubes as Efficient Hybrid Transfer Hydrogenation Catalyst

A half-sandwich ruthenium-p-cymene organometallic complex has been immobilized at Single Walled Carbon Nanotubes (SWNT) sidewalls through a stepwise covalent chemistry protocol. The introduction of amino groups by means of diazonium-chemistry protocols leads the grafting at the outer walls of the nanotubes. This hybrid material is active in the transfer hydrogenation of ketones to yield alcohols, using as hydrogen source 2-propanol. SWNT?NH2?Ru presents a broad scope, performing the reaction under aerobic conditions and can be recycled over 9 consecutive reaction runs without losing activity or leaching ruthenium out. Comparison of the activity with related homogeneous catalysts reveals an improved performance due to the covalent bond between the metal and the material, achieving turnover frequencies as high as 192774 h?1.

Diastereoselective Diboration of Cyclic Alkenes: Application to the Synthesis of Aristeromycin

The Pt-catalyzed diboration of cyclic alkenes is extended to unsaturated heterocycles and bicyclic compounds and can be accomplished in a diastereoselective fashion. The optimal procedures, substrate scope, and diastereoselectivity were investigated, and examples employing both homogeneous and heterogeneous catalysis were examined. Lastly, application to the construction of the nucleoside analog (±)-aristeromycin was conducted.

Effective synthesis of bicyclodienes via palladium-catalyzed asymmetric allylic alkylation and ruthenium-catalyzed cycloisomerization

[n.3.0]Bicycles (n = 3-6) can be synthesized using palladium-catalyzed asymmetric allylic alkylation followed by rutheniumcatalyzedcycloisomerization.Newtypesoftriarylphosphino-1,2-diaminooxazolineligandsshowthesamehighlevelsofenantioselectivity observed with Trost ligand when employed in Pd-catalyzed allylic alkylation reactions. The enyne products of these allylic alkylation reactions were further elaborated using a Ru-catalyzed redox isomerization process, for which a mechanism is proposed.

Pd-catalyzed regioselective C?H alkenylation and alkynylation of allylic alcohols with the assistance of a bidentate phenanthroline auxiliary

A Pd-catalyzed regioselective C?H alkenylation of allylic alcohols with electron-deficient alkenes has been developed. The key to success is the introduction of bidentately coordinating phenanthroline directing group, which enables the otherwise challenging and regioselective C?H activation at the proximal alkenyl C?H bonds over the conceivably competitive allylic C?O bond activation. The same Pd/phenanthroline system is efficient for the C?H alkynylation of allylic alcohols with alkynyl bromides.

Cyclotriol derivative and production method and application thereof

The invention discloses a cyclotriol derivative and a production method and application thereof. The cyclotriol derivative is of a structure as shown in a general formula I, wherein R1, R2 and R3 areOH or AcNH; R1=OH, and R2=R3=AcNH or R2=OH, and R1=R3=AcNH or R3=OH, and R1=R2=AcNH; * stands for R configuration or S configuration; and Ac stands for caffeoyl CAc or derivatives caffesulfonyl SAc and caffe(mono-methyl ester)phosphonyl PAc of the caffeoyl CAc. According to the production method of the cyclotriol derivative, conditions are mild, automatic and industrial production are easy to achieve, operation is simple, convenient and safe, and the obtained cyclotriol derivative can act on anti-respiratory syncytial virus F protein, has high anti-RSV activity, low cell toxicity and high stability, can be used for producing medicines for treating virus infection, and is especially used for producing medicines for treating respiratory syncytial virus infection.

HFIP Solvent Enables Alcohols to Act as Alkylating Agents in Stereoselective Heterocyclization

A new method for the stereoselective synthesis of highly functionalized oxygen heterocycles using allyl or benzyl alcohols as alkylating agents is presented. The process is efficient and atom economic, generating water as the only stoichiometric byproduct. Substoichiometric amounts of Ti(OiPr)4 in HFIP solvent are key to this reactivity, and the method tolerates a broad substitution pattern on both the alcohol initiator and homoallylic alcohol substrate. Preliminary mechanistic studies reveal in situ formation of a titanium complex with HFIP which may initiate the cyclization reaction. Further stereoselective functionalization of the products allows access to a diverse range of interesting heterocyclic structures.

Chemoselective Luche-Type Reduction of α,β-Unsaturated Ketones by Magnesium Catalysis

The chemoselective reduction of α,β-unsaturated ketones by use of an economic and readily available Mg catalyst has been developed. Excellent yields for a wide range of ketones have been achieved under mild reaction conditions, short times, and low catalyst loadings (0.2-0.5 mol %).

Raceme (4AS,7S,7AS)-tert-butyl-7-hydroxyhexahydrocyclopentadiene[B][1,4]oxazine-4(4AH)-formate preparation method

A purpose of the present invention is to develop a raceme (4AS,7S,7AS)-tert-butyl-7-hydroxyhexahydrocyclopentadiene[B][1,4]oxazine-4(4AH)-formate preparation method so as to mainly solve the technicalproblem that no synthesis method exists in the prior art. According to the present invention, the method comprises seven steps, and the reaction formula is defined in the specification; and the prepared compound can be used as the useful intermediate or product for synthesizing a plurality of medicines.