62898-76-4Relevant academic research and scientific papers
A mild Bischler–Napieralski-type cyclization of trichloromethyl carbamates for the synthesis of β -carbolinones
Hirao, Seiya,Kitamori, Mayumi,Itoh, Tomoki,Chiba, Yuusuke,Abe, Takumi
, p. 235 - 250 (2020/02/11)
– A straightforward synthesis of β-carbolinones by the Bischler–Napieralski-type cyclization of the corresponding trichloromethyl carbamates, which does not require acids, bases, oxidants, or transition-metals to promote the cyclization, has been achieved.
Palladium-catalyzed cross-coupling reactions of potassium n-methyltrifluoroborate isoindolin-1-one with aryl and heteroaryl chlorides
Nadaf, Rashid N.,Seapy, Dave G.
, p. 2012 - 2020 (2014/07/07)
Potassium N-methyltrifluoroborate isoindolin-1-one was synthesized and used in Suzuki-Miyaura palladium-catalyzed cross-coupling reactions with aryl and heteroaryl chlorides to prepare 29 examples of substituted N-benzyl isoindolin-1-ones. The new approach benefits from mild reaction conditions that tolerate a variety of functional groups. In addition, because of the large number of commercially available aryl and heteroaryl chlorides that can serve as coupling partners, the approach readily provides access to libraries of substituted N-benzyl isoindolin-1-ones. Copyright
