62898-99-1

Usage

Chemical structure

Pyrimidine derivative

Appearance

White crystalline solid

Solubility

Soluble in organic solvents, insoluble in water

Applications

a. Pharmaceutical industry
b. Pesticides
c. Dyes
d. Building block for synthesis of bioactive compounds

Ongoing research

Further investigation into its properties and applications in various industries

Upstream product

• 64-67-5 diethyl sulfate 
• 55996-28-6 6-methyl-2-methoxy-4(3H)-pyrimidinone 
• 626-48-2 6-Methyluracil 
• 75-03-6 ethyl iodide 

Downstream Products

• 1614252-44-6 5-benzoyl-1,3-diethyl-6-methylpyrimidine-2,4(1H,3H)-dione 
• 1614249-54-5 10-(5-chlorofuran-2-yl)-1,3-diethyl-5-phenyl-7,8-dihydro-1H-pyrimido[4',5':3,4]pyrrolo[2,1-c][1,4]thiazine-2,4(3H,10H)-dione 
• 1614252-43-5 1,3-diethyl-6-(2-mercaptoethyl)-5-phenyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione 
• 1614252-46-8 1,3-diethyl-5-phenyl-6-(2-(tritylthio)ethyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione 
• 1614252-45-7 5-benzoyl-6-(bromomethyl)-1,3-diethylpyrimidine-2,4(1H,3H)-dione 

Relevant academic research and scientific papers

HSAB driven chemoselectivity in alkylation of uracil derivatives. A high yielding preparation of 3-alkylated and unsymmetrically 1,3-dialkylated uracils

A qualitative hardness scale (N134) has been found for the conjugated bases of 2-methoxy-4(3H)-pyrimidinones 1-3 and applied to high yielding chemoselective N3 methylation, ethylation and benzylation reactions. Removal of the 2-methoxy group followed by a second alkylation affords unsymmetrically 1,3-disubstituted uracils.

A diversity of alkylation/acylation products of uracil and its derivatives: Synthesis and a structural study

tert-Butyl dicarbonate (Boc2O) and ethyl iodide (EtI) reactions with uracil (U), thymine (T) and 6-methyluracil (6-MU) were performed following routine procedures in pyridine/DMF solvents and with DMAP as the catalyst. Among 20 synthesized compounds, a derivative of 6-methyluracil substituted by the Boc-pyridine moiety at the C5 position appeared unexpectedly. The NMR spectra confirmed the molecular structure of all uracil derivatives. Parallel quantum mechanical DFT calculations supported the experimental findings.