62918-30-3

Upstream product

• 941-98-0 1'-naphthacetophenone 
• 4251-65-4 (4-chlorophenyl)acetaldehyde 
• 91-20-3 naphthalene 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 170939-88-5 [4-(4-Chloro-phenyl)-1H-pyrrol-3-yl]-naphthalen-1-yl-methanone 
• 170938-96-2 1-{[4-(4-Chloro-phenyl)-1H-pyrrol-3-yl]-naphthalen-1-yl-methyl}-1H-imidazole 
• 154371-82-1 C₂₅H₁₉ClN₂ 
• 1058061-95-2 4-(4-chlorophenyl)-2-(naphthalen-1-yl)quinoline 

Relevant academic research and scientific papers

Synthesis of chalcones derived from 1-naphthylacetophenone and evaluation of their cytotoxic and apoptotic effects in acute leukemia cell lines

Chalcones and their derivatives have been described as promising compounds with antiproliferative activity against leukemic cells. This study aimed to investigate the cytotoxic effect of three synthetic chalcones derived from 1-naphthylacetophenone (F07,

Pyrazoles and pyrazolines as anti-inflammatory agents

The five-membered heterocyclic group of pyrazoles/pyrazolines plays important role in drug discovery. Pyrazoles and pyrazolines present a wide range of biological activities. The synthesis of the pyrazolines and pyrazole derivatives was accomplished via t

Naphthalene-triazolopyrimidine hybrid compounds as potential multifunctional anti-Alzheimer's agents

In an attempt to construct potential anti-Alzheimer's agents Naphthalene-triazolopyrimidine hybrids were synthesized and screened in vitro against the two cholinesterases (ChE)s, amyloid β aggregation and for antioxidation activity. Single-crystal X-ray c

Two hydrazones derived from 1-aryl-3-(P-substituted phenyl)prop-2-en-1-one: Synthesis, crystal structure, hirshfeld surface analysis and in vitro biological properties

Two chalcones were synthesized by the aldolic condensation of enolizable aromatic ketones with substituted benzaldehydes under Claisen–Schmidt reaction conditions and then treated with 2,4-dinitrophenylhydrazine to yield their corresponding hydrazones. Th

N1-benzenesulfonyl-2-pyrazoline hybrids in neurological disorders: Syntheses, biological screening and computational studies

A novel series of 1,3,5-trisubstituted-2-pyrazolines (5a-5t) was prepared via Claisen Schmidt condensation, followed by heterocyclization with hydrazine hydrate, substitution of N1 hydrogen of 2-pyrazoline nucleus with 4-chlorobenzenesulfonylchloride, app

Derivatives of 4,5-dihydro (1H) pyrazoles as possible MAO-A inhibitors in depression and anxiety disorders: synthesis, biological evaluation and molecular modeling studies

A series of 1,3,5-trisubstituted-2-pyrazoline derivatives (3a–3t) were synthesized in appreciable yields by substituting N1 position of 2-pyrazoline nucleus with 4-nitrobenzenesulfonylchloride using conventional and microwave assisted synthetic approaches

An expeditious one-pot microwave facilitated versus conventional syntheses: In vivo biological screening and molecular docking studies of some 3,5-disubstituted-4,5-dihydro-(1H)-pyrazole derivatives

A series of 3,5-disubstituted-2-pyrazoline derivatives (2a-2t) were synthesized by reacting different aromatic/heteroaromatic aldehydes and ketones, in a two-step reaction through Claisen Schmidt condensation, followed by cyclization of the resulted chalc

Synthesis and screening of substituted chalcones as lipoxygenase inhibitors

The present work involved the synthesis of chalcone derivatives, their characterization and in vitro evaluation for lipoxygenase inhibitory activity. The synthesis of chalcone derivatives was carried out in one step employing Claisen Schmidt condensation.

Synthesis and biological evaluation of some new naphthyl derivatives as anti-microbial activity

IN CONECTION with our previous interest in developing new approaches for synthesis of heterocyclic utilizing readily obtainable starting materials, we reported here synthesis of a new heterocyclic utilizing 1-acetyl naphthalene. Reaction of acetyl naphtha

Synthesis of new 3-(4-fluoronaphthyl)-5-(aryl)-2-isoxazolines and their antimicrobial and spermicidal activity

Microwave assisted synthesis of 3-(4-fluoronaphthyl)-5-(aryl)-2- isoxazolines (3) from corresponding chalcones (2) and hydroxylamine hydrochloride has been accomplished. Structures of synthesized compounds have been confirmed on the basis of spectral studies (IR, 1H NMR) and analytical data. Representative compounds have been screened for their spermicidal activity in HF cattle and were also evaluated for their antibacterial activity against Staphylococcus aureus, E coli, Pseudomonas and antifungal activity against Candida albicans, Asperigillus niger, Fusarium oxysporum.