62937-31-9Relevant academic research and scientific papers
Blaise reaction of ethyl 3-bromodifluoromethyl-3-benzyloxyacrylate with nitriles: A convenient synthesis of α-difluorovinyl-substituted β-enaminoesters and β-ketoesters
Peng, Weimin,Zhao, Jingwei,Zhu, Shizheng
, p. 1470 - 1474 (2006)
The Blaise reaction between the zinc dienolate of ethyl 3-bromodifluoromethyl-3-benzyloxyacrylate and a variety of nitriles gave a series of α-difluorovinyl substituted β-enaminoesters in good yield, which readily underwent hydrolysis to the corresponding
1,2-Migration in rhodium(II) carbene transfer reaction: Remarkable steric effect on migratory aptitude
Xiao, Fengping,Wang, Jianbo
, p. 5789 - 5791 (2007/10/03)
A series of diazo carbonyl compounds bearing different substituents have been prepared in order to investigate the steric effect in 1,2-migration reaction of rhodium(II) carbene. Through the investigation on the diazo decomposition of these compounds with Rh2(OAc)4, it was found that the steric effect could dramatically influence the migratory aptitude. In many cases, the steric effect could override the inherent electronic effect of the substituent.
Determination of keto-enol equilibrium constants and the kinetic study of the nitrosation reaction of β-dicarbonyl compounds
Iglesias, Emilia
, p. 431 - 439 (2007/10/03)
The keno-enol equilibrium constants of acetylacetone, ethyl acetoacetate and ethyl benzoylacetate in water at 25°C are determined by studying the influence of surfactants on their UV-VIS spectra, following the method applied to benzoylacetone published recently. These measured equilibrium constants are used to obtain the reactivity of the ketones towards several nitrosating agents. For this end, the nitrosation reaction of benzoylacetone, acetylacetone, ethyl acetoacetate and ethyl benzoylacetate are studied in aqueous acidic solution in the presence and absence of Cl-, Br- or SCN-. Analysis of the kinetic data indicates that the rate-limiting step is, in every case, the reaction of the enol.
