54828-00-1

Upstream product

• 51-80-9 bis-(dimethylamino)methane 
• 106-48-9 4-chloro-phenol 
• 70112-21-9 N,N-dimethyl-2-hydroxy-5-chlorobenzamide 
• 50-00-0 formaldehyd 
• 124-40-3 dimethyl amine 

Downstream Products

• 100-02-7 4-nitro-phenol 
• 73671-65-5 4-chloro-2-(1H-imidazol-1-ylmethyl)phenol 
• 95062-48-9 4-chloro-1,2-quinodimethane 
• 6296-65-7 1-(5-chloro-2-hydroxyphenyl)-N,N,N-trimethylmethanaminium iodide 
• 73779-25-6 2-(2-Benzenesulfonyl-ethyl)-4-chloro-phenol 

Relevant academic research and scientific papers

Convenient synthesis of 2-Amino-4H-chromenes from photochemically generated o-quinone methides and malononitrile

2-Amino-4H-chromenes were synthesized in moderate to good yields by the reaction of o-quinone methides photochemically generated from o-(dimethylaminomethyl)phenols with malononitrile. This method was applicable to the synthesis of fluorinated chromenes that were difficult to obtain by other methods. In addition, o-(hydroxymethyl)phenols could be used for the reaction in the presence of tertiary amine bases.

BENZIMIDAZOLE COMPOUNDS

There is provided a compound of the formula (1) wherein R1 is an optionally substituted C1-10 alkyl; R2 is H, or a C1-6 alkyl which may be substituted with 1 to 3 substituents; R3 is a 5- or 6-membered aromatic group which may be substituted with 1 to 5 substituents, wherein the 5- or 6-membered aromatic group may be fused with a 5- or 6- membered ring which may be substituted with 1 to 3 C1-6 alkyls; R4 is a hydrogen, a halogen, a hydroxy, a cyano, a C1-6 alkyl or a C1-6 alkoxy; Z is -O-, -S-, -SO-, -SO2-, or - NR5- wherein R5 is a hydrogen or a C1-6 alkyl; or a salt thereof or a prodrug thereof, which have CRF receptor antagonist activity and use thereof.

2-(aminoalkoxy) phenylalkylamines with antiinflammatory activity

Compounds of the formula I STR1 including pharmaceutically acceptable salts thereof are disclosed in which R1, R2, R3, and R4 independently represent hydrogen, hydroxy, halo, halogenated alkyl, halogenated alkox