6296-89-5

Basic information

• Product Name: 4-HYDRAZINOBENZOIC ACID METHYL ESTER HYDROCHLORIDE
• Synonyms: 4-HYDRAZINOBENZOIC ACID METHYL ESTER HYDROCHLORIDE;AURORA 1803;Benzoic acid, 4-hydrazino-, Methyl ester, Monohydrochloride;Methyl 4-hydrazinylbenzoate hydrochloride;methyl 4-hydrazinobenzoate hydrochloride
• CAS NO: 6296-89-5
• Molecular Formula: C₈H₁₀N₂O₂*ClH
• Molecular Weight: 202.64
• Mol File: 6296-89-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 205-207 °C
• Boiling Point: 318.6°C at 760 mmHg
• Flash Point: 146.5°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 0.000357mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-HYDRAZINOBENZOIC ACID METHYL ESTER HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDRAZINOBENZOIC ACID METHYL ESTER HYDROCHLORIDE(6296-89-5)
• EPA Substance Registry System: 4-HYDRAZINOBENZOIC ACID METHYL ESTER HYDROCHLORIDE(6296-89-5)

Safety Data

• Hazardous Substances Data: 6296-89-5(Hazardous Substances Data)

Usage

Uses

Methyl 4-hydrazinylbenzoate HCl

InChI:InChI=1/C8H10N2O2/c1-12-8(11)6-2-4-7(10-9)5-3-6/h2-5,10H,9H2,1H3

Upstream product

• 5326-27-2 2-hydrazino-benzoic acid 
• 619-45-4 4-methoxycarbonyl aniline 
• 67-56-1 methanol 
• 24589-77-3 4-hydrazinobenzoic acid hydrochloride 

Downstream Products

• 1048668-71-8 methyl 4-[4-(2-Adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoate 
• 1048668-73-0 methyl 4-[4-(2-adamantylcarbamoyl)-5-(1-methylcyclopropyl)pyrazol-1-yl]benzoate 
• 1048668-75-2 methyl 4-[4-(2-adamantylcarbamoyl)-5-cyclopentylpyrazol-1-yl]benzoate 
• 1048669-27-7 tert-butyl 5-amino-1-(4-methoxycarbonylphenyl)pyrazole-4-carboxylate 
• 1048669-30-2 methyl 4-[5-amino-4-(cyclohexylcarbamoyl)pyrazol-1-yl]benzoate 
• 1187877-97-9 methyl 4-{5-[4-(hydroxymethyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}benzoate 
• 1027232-57-0 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-1-pyrazolyl)benzoic acid methyl ester 
• 1203704-02-2 1-(4-carbomethoxyphenyl)-4-phenylpyrazole 
• 83326-44-7 2-acetyl-1-(methyl 4-phenylcarboxylate)hydrazine 
• 1048668-70-7 4-[4-(2-adamantylcarbamoyl)-5-tert-butylpyrazol-1-yl]benzoic acid 
• 124397-38-2 4-methoxycarbonylbenzenesulphonyl fluoride 
• 720-75-2 methyl 4-phenylbenzoate 
• 93-58-3 benzoic acid methyl ester 

Relevant articles and documents

A greener approach for the large-scale synthesis of 1,4,5-trisubstituted pyrazole, AZD8329

The development of a convenient, safe and scalable process for AZD8329 manufacturing is reported here. Synthesis was achieved in a two-step telescopic process with an excellent overall yield of 75%. In the first step enamine (6) was synthesized with 90% yield through three chemical transformations. In the next step AZD8329 was synthesized from the reactions of 6 and 4-hydrazinobenzoic acid hydrochloride 7 through two chemical transformations. The process is very efficient and economical, and AZD8329 was manufactured in multikilogram scale. A greener approach is demonstrated through usage of a minimum number of solvents and energy and with process mass intensity (PMI) 60 in the manufacturing process.

PYRAZOLE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS

A compound of formula (I): and pharmaceutically -acceptable salts thereof wherein the variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are also described.