629645-53-0

Basic information

• Product Name: tert-butyl (4-hydroxypyrimidin-2-yl)carbamate
• Synonyms: tert-butyl (4-hydroxypyrimidin-2-yl)carbamate;(1,4-Dihydro-4-oxo-2-pyrimidinyl)carbamic acid 1,1-dimethylethyl ester
• CAS NO: 629645-53-0
• Molecular Formula: C₉H₁₃N₃O₃
• Molecular Weight: 211
• Mol File: 629645-53-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl (4-hydroxypyrimidin-2-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (4-hydroxypyrimidin-2-yl)carbamate(629645-53-0)
• EPA Substance Registry System: tert-butyl (4-hydroxypyrimidin-2-yl)carbamate(629645-53-0)

Safety Data

• Hazardous Substances Data: 629645-53-0(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 108-53-2 2-amino-4-hydroxypyrimidine 

Downstream Products

• 1464788-84-8 4-chloro-2-amino(bis-carbamate)pyrimidine 
• 629645-60-9 t-butyl 4-(N-(4-bromophenyl)ethanehydrazonoyl)pyrimidin-2-ylcarbamate 
• 629645-59-6 tert-butyl 4-(N-phenylethanehydrazonoyl)pyrimidin-2-ylcarbamate 
• 629645-58-5 tert-butyl [4-acetylpyrimidin-2-yl]carbamate 
• 629645-55-2 tert-butyl (4-chlopropyrimidin-2-yl)carbamate 

Relevant articles and documents

Macrocyclic JAK2 inhibitor and application thereof

The invention relates to a macrocyclic JAK2 inhibitor and an application thereof. Specifically, the invention relates to a compound shown as a formula I and an application of the compound in treatingJAK2-mediated related diseases and preparing medicines for treating the JAK2-mediated related diseases.

ANTI-ANGIOGENESIS COMPOUND, INTERMEDIATE AND USE THEREOF

Disclosed are an anti-abnormal proliferation of angiogenesis compound represented by formula I, use and intermediate thereof. The compound has good effect against abnormal proliferation of angiogenesis, and the activity of the compound is produced by inhibiting VEGFR2. The compound can be used for treating diseases, such as wet macular degeneration, inflammation, malignant tumor and the like, caused by abnormity of angiogenesis and protein kinases such as VEGFR2, FGFR2 and the like.

Synthesis of 2-(pyrimidin-4-yl)indoles

The synthesis of 2-substituted isomers of the meridianins, a familiy of bioactive indole alkaloids isolated from the tunicate Aplidium meridianum, was undertaken. The synthetic route comprises six steps, with a microwave promoted Fischer cyclization as th