1464788-84-8

Basic information

• Product Name: di-tert-butyl (4-chloropyriMidin-2-yl)carbaMate
• Synonyms: di-tert-butyl (4-chloropyriMidin-2-yl)carbaMate;N,N'-Di-Boc-2-aMino-4-chloropyriMidine;tert-Butyl tert-butyl(4-chloropyrimidin-2-yl)carbamate;Di-tert-butyl (4-chloropyrimidin-2-yl)imidodicarbonate;4-chloro-2-amino(bis-carbamate)pyrimidine;tert-Butyl N-tert-butoxycarbonyl-N-(4-chloropyrimidin-2-yl)carbamate;4-Chloro-2-[bis(tert-butoxycarbonyl)amino]pyrimidine
• CAS NO: 1464788-84-8
• Molecular Formula: C13H20ClN3O2
• Molecular Weight: 285.7698
• Mol File: 1464788-84-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 399.7±34.0 °C(Predicted)
• Appearance: /
• Density: 1.244±0.06 g/cm3(Predicted)
• PKA: -0.87±0.10(Predicted)
• CAS DataBase Reference: di-tert-butyl (4-chloropyriMidin-2-yl)carbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: di-tert-butyl (4-chloropyriMidin-2-yl)carbaMate(1464788-84-8)
• EPA Substance Registry System: di-tert-butyl (4-chloropyriMidin-2-yl)carbaMate(1464788-84-8)

Safety Data

• Hazardous Substances Data: 1464788-84-8(Hazardous Substances Data)

Usage

General Description

Di-tert-butyl (4-chloropyrimidin-2-yl)carbamate, also known as Profluralin, is a chemical compound commonly used as a herbicide to control weeds in agricultural crops. It is a white crystalline solid that is insoluble in water but soluble in organic solvents. Profluralin works by inhibiting the growth of roots in germinating weed seeds, preventing them from establishing and competing with desired crops. It is applied to the soil before planting and is effective against a wide range of annual grasses and broadleaf weeds. However, it is important to handle this chemical with care as it can be harmful if ingested or inhaled, and can cause skin and eye irritation. Proper safety precautions and protective equipment should be used when handling and applying profluralin.

Upstream product

• 629645-53-0 tert-butyl (4-hydroxypyrimidin-2-yl)carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 629645-55-2 tert-butyl (4-chlopropyrimidin-2-yl)carbamate 
• 3993-78-0 2-amino-4-chloropyrimidine 

Relevant articles and documents

ANTI-ANGIOGENESIS COMPOUND, INTERMEDIATE AND USE THEREOF

Disclosed are an anti-abnormal proliferation of angiogenesis compound represented by formula I, use and intermediate thereof. The compound has good effect against abnormal proliferation of angiogenesis, and the activity of the compound is produced by inhibiting VEGFR2. The compound can be used for treating diseases, such as wet macular degeneration, inflammation, malignant tumor and the like, caused by abnormity of angiogenesis and protein kinases such as VEGFR2, FGFR2 and the like.

ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS

The invention relates to compounds inhibiting phosphoinositide 3-kinases (PI3K), to pharmaceutical compositions comprising them and therapeutic use thereofin the treatment of disorders associated with PI3K enzymes.

INDOLE-PYRIMIDINE DERIVATIVES AND THEIR THERAPEUTIC USES

The present invention relates to new indole-pyrimidine derivatives of Formula (I), a process for obtaining them, a pharmaceutical composition comprising said compounds and their use in the treatment of several disease including cognitive, neurodegenerative or neurological diseases or conditions, diabetes, inflammatory and autoimmune diseases and cardiovascular disorders.