62987-05-7

Basic information

• Product Name: FD 1
• Synonyms: 1,3-Bis(tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione;1,3-Bis(tetrahydrofuran-2-yl)-5-fluorouracil;5-Fluoro-1,3-bis(tetrahydrofuran-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione;5-Fluoro-1,3-bis(tetrahydrofuran-2-yl)-2,4(1H,3H)-pyrimidinedione;FD-1【antitumor agent】
• CAS NO: 62987-05-7
• Molecular Formula: C₁₂H₁₅FN₂O₄
• Molecular Weight: 270.29
• Mol File: 62987-05-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 104-106 °C
• Boiling Point: 379.5°C at 760 mmHg
• Flash Point: 183.3°C
• Appearance: /
• Density: 1.2650 (estimate)
• Vapor Pressure: 5.81E-06mmHg at 25°C
• Refractive Index: 1.575
• PKA: -4.42±0.40(Predicted)
• CAS DataBase Reference: FD 1(CAS DataBase Reference)
• NIST Chemistry Reference: FD 1(62987-05-7)
• EPA Substance Registry System: FD 1(62987-05-7)

Safety Data

• Hazardous Substances Data: 62987-05-7(Hazardous Substances Data)

Usage

General Description

FD 1 is a chemical compound that falls under the class of aphrodisiacs, and is commonly used in the production of perfumes and fragrances. It is also believed to possess certain mood-enhancing properties and is often used in aromatherapy products. However, it should be noted that the use of FD 1 in certain applications may be restricted due to its potential for causing allergic reactions in sensitive individuals. Overall, FD 1 is a versatile and popular chemical in the fragrance and cosmetics industries, known for its aromatic and mood-boosting properties.

InChI:InChI=1/C12H15FN2O4/c13-8-7-14(9-3-1-5-18-9)12(17)15(11(8)16)10-4-2-6-19-10/h7,9-10H,1-6H2

Upstream product

• 1608-67-9 2-acetoxytetrahydrofuran 
• 51-21-8 5-fluorouracil 
• 1191-99-7 2,3-dihydro-2H-furan 
• 13369-70-5 2-chlorotetrahydrofuran 

Downstream Products

• 17902-23-7 tegafur 

Relevant articles and documents

Synthesis of Tegafur by the Alkylation of 5-Fluorouracil under the Lewis Acid and Metal Salt-Free Conditions

A novel protocol for preparation of tegafur (a prodrug of 5-fluorouracil) is reported. The process involves the 1,8-diazabicycloundec-7-ene-mediated alkylation of 5-fluorouracil with 2-acetoxytetrahydrofuran at 90 °C, followed by treatment of the prepurified mixture of the alkylation products with aqueous ethanol at 70 °C. The yield of the two-step process is 72%.

5-Fluorouracil derivatives. X. Synthesis and antitumor activities of α-alkoxyalkyl-5-fluorouracils

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Process for producing 5-fluorouracil derivative with a calcium chloride catalyst

5-Fluorouracil derivative having the formula STR1 wherein R represents hydrogen atom or 2-tetrahydrofuryl group is produced by reacting more than equi-mole of 2,3-dihydrofuran with 5-fluorouracil in a polar aprotic solvent with a catalytically effective amount of a catalyst selected from the group consisting of metal halides, non-metal halides, tertiary amine salt of inorganic acids and organic acids in neutral or basic condition at 50° to 150° C under pressure.