1608-67-9

Basic information

• Product Name: tetrahydro-2-furyl acetate
• Synonyms: tetrahydro-2-furyl acetate;Acetic acid tetrahydrofuran-2-yl ester;acetic acid tetrahydrofuryl ester;oxolan-2-yl acetate;oxolan-2-yl ethanoate;tetrahydrofuran-2-yl acetate;2-Furanol,tetrahydro-, 2-acetate;tetrahydro-2-furanyl acetate
• CAS NO: 1608-67-9
• Molecular Formula: C₆H₁₀O₃
• Molecular Weight: 130.1418
• EINECS: 216-536-5
• Mol File: 1608-67-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 164.9 °C at 760 mmHg
• Flash Point: 58.1 °C
• Appearance: /
• Density: 1.08 g/cm³
• Vapor Pressure: 1.92mmHg at 25°C
• Refractive Index: 1.437
• CAS DataBase Reference: tetrahydro-2-furyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: tetrahydro-2-furyl acetate(1608-67-9)
• EPA Substance Registry System: tetrahydro-2-furyl acetate(1608-67-9)

Safety Data

• Hazardous Substances Data: 1608-67-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron, 21, p. 871, 1965 DOI: 10.1016/0040-4020(65)80022-9

InChI:InChI=1/C6H10O3/c1-5(7)9-6-3-2-4-8-6/h6H,2-4H2,1H3

Upstream product

• 109-99-9 tetrahydrofuran 
• 5183-78-8 methyl(phenylsulfonyl)amide 
• 110-63-4 Butane-1,4-diol 
• 87413-09-0 Dess-Martin periodane 
• 1191-99-7 2,3-dihydro-2H-furan 
• 64-19-7 acetic acid 

Downstream Products

• 17902-22-6 5-methyl-1-(tetrahydrofuran-2-yl)pyrimidine-2,4-dione 
• 17902-23-7 tegafur 
• 63901-83-7 5-fluoro-3-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 
• 62987-05-7 1,3-bis(tetrahydro-2-furyl)-5-fluorouracil 
• 79994-85-7 C₈H₈⁽²⁾HFN₂O₃ 
• 79994-86-8 C₈H₇⁽²⁾H₂FN₂O₃ 
• 51112-64-2 6-(methylthio)-9-(tetrahydrofuran-2-yl)-9H-purine 
• 91366-99-3 6-chloro-9-(tetrahydro-2-furanyl)-9H-purine 
• 17318-31-9 9-(tetrahydro-2-furanyl)-9H-purine-6-amine 
• 92658-75-8 9-tetrahydrofuran-2-yl-1,9-dihydro-purin-6-one 
• 68136-74-3 5-methyl-1,3-bis-tetrahydrofuran-2-yl-1H-pyrimidine-2,4-dione 

Relevant articles and documents

-

-

Metal-free amidation of ether sp3 C-H bonds with sulfonamides using PhI(OAc)2

A selective protocol for the metal-free α-C-H amidation of ethers using sulfonamides and hypervalent iodine oxidants has been developed. The absence of precious metals and the conditions employed make the method environmentally attractive. A number of cyclic and acyclic, linear and branched ethers have been successfully amidated, and a broad sulfonamide scope has been demonstrated. Two unusual reactions, namely the amidation of an unactivated tert-butyl group and a tandem C-C coupling reaction, are also described. This journal is

Iron(III) triflate-catalyzed one-pot synthesis of acetal-type protected cyanohydrins from carbonyl compounds

A variety of cyanohydrin THP ethers were readily prepared from carbonyl compounds with trimethylsilyl cyanide and tetrahydropyran-2-yl acetate under the influence of a catalytic amount of iron(III) triflate in a convenient one-pot procedure. This method was also effective to prepare O-protected cyanohydrins by various acetal-type protective groups.