63000-00-0Relevant academic research and scientific papers
Visible-Light Mediated Photooxidative Phosphorylation of Benzylamines: A Novel and Mild Pathway Towards α-Aminophosphorus Compounds
Ung, Sosthène P.-M.,Perepichka, Inna,Li, Chao-Jun
, (2021/12/09)
Traditional syntheses of α-aminophosphorus therapeutic targets proceed through the hydrophosphorylation of C=N or C=O bonds, thus necessitating preliminary oxidized substrates. Cross-dehydrogenative coupling strategies can bypass this extra oxidation step by oxidizing simpler substrates in situ before phosphorylating them, but those protocols can suffer from the use of toxic stoichiometric oxidants. Photochemical strategies can access those oxidized intermediates without any harsh conditions and can use molecular oxygen as a benign and sustainable oxidant. We report herein a simple protocol using visible light, phosphinylidenes and benzylamine derivatives for the synthesis of α-aminophosphorus products under aerobic conditions and using an iridium photosensitizer.
Efficient synthesis of α-aminophosphonates via one-pot reactions of aldehydes, amines, and phosphates in ionic liquid
Hajinasiri, Rahimeh,Hossaini, Zinatossadat,Rostami-Charati, Faramarz
experimental part, p. 625 - 629 (2011/12/04)
Ionic liquids such as 1,3-dialkylimidazolium bromides make excellent solvents for synthesis of α-aminophosphonates from aldehydes, amines, and phosphites. The ionic liquids are successfully regenerated and reused. Copyright
Facile synthesis of α-amino phosphonates in water by Kabachnik-Fields reaction using magnesium dodecyl sulfate
Ando, Kaori,Egami, Tomoe
experimental part, p. 358 - 362 (2012/01/06)
The three-component reaction of aldehydes, amines and triethyl or diphenyl phosphite was efficiently catalyzed by magnesium dodecyl sulfate at room temperature in water to give various α-amino phosphonates in high yields. The catalyst is easily available from inexpensive sodium dodecyl sulfate and magnesium bromide.
