63006-93-9

Basic information

• Product Name: 1,2,3,4-Tetrahydroisoquinoline-3-methanol
• Synonyms: 3-HYDROXYMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE;AKOS BB-8834;1,2,3,4-TETRAHYDROISOQUINOLINE-3-METHANOL;1,2,3,4-tetrahydro-3-isoquinolineMethanol;3-IsoquinolineMethanol,1,2,3,4-tetrahydro-
• CAS NO: 63006-93-9
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.22
• Product Categories: pharmacetical;Aromatics
• Mol File: 63006-93-9.mol
• Article Data: 23

Chemical Properties

• Melting Point: 180-182?C
• Boiling Point: 307.9 °C at 760 mmHg
• Flash Point: 147 °C
• Appearance: /Crystalline
• Density: 1.081 g/cm³
• Vapor Pressure: 0.000305mmHg at 25°C
• Refractive Index: 1.549
• Storage Temp.: -20?C Freezer
• PKA: 14.57±0.10(Predicted)
• Water Solubility: Soluble in dichloromethane. Slightly soluble in water.
• CAS DataBase Reference: 1,2,3,4-Tetrahydroisoquinoline-3-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-Tetrahydroisoquinoline-3-methanol(63006-93-9)
• EPA Substance Registry System: 1,2,3,4-Tetrahydroisoquinoline-3-methanol(63006-93-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 63006-93-9(Hazardous Substances Data)

Usage

Chemical Properties

Light Orange Solid

Uses

rac 1,2,3,4-Tetrahydroisoquinoline-3-methanol (cas# 63006-93-9) is a compound useful in organic synthesis.

InChI:InChI=1/C10H13NO/c12-7-10-5-8-3-1-2-4-9(8)6-11-10/h1-4,10-12H,5-7H2

Upstream product

• 67123-97-1 (R,S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 50-00-0 formaldehyd 
• 63-91-2 L-phenylalanine 
• 63-91-2 L-phenylalanine 
• 79815-19-3 methyl (3S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate 
• 62708-42-3 o-allylbenzaldehyde 
• 1510832-00-4 (S)-(2-((4-nitrophenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methanol 
• 15912-55-7 ethyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 77497-95-1 (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride 
• 74163-81-8 L-Tic-OH 
• 15912-56-8 ethyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride 
• 77497-96-2 (S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, phenylmethylester 
• 57060-86-3 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 15912-55-7 ethyl 1,2,3,4-tetrahydroisoquinoline-3-(S)-carboxylate 

Downstream Products

• 114784-14-4 (S)-4-Benzyloxycarbonylamino-5-((S)-3-hydroxymethyl-3,4-dihydro-1H-isoquinolin-2-yl)-5-oxo-pentanoic acid methyl ester 
• 114784-11-1 2-[2-Benzyloxycarbonylamino-3-((S)-3-hydroxymethyl-3,4-dihydro-1H-isoquinolin-2-yl)-3-oxo-propyl]-malonic acid dimethyl ester 
• 243858-66-4 N-tert-butyloxycarbonyl-1,2,3,4-tetrahydroisoquinoline-3-methanol 
• 914083-31-1 Sulfamic acid (S)-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethyl ester 
• 782500-97-4 (2'S,3S)-2-(2'-benzyloxy-5'-methylhex-4'-enyl)-1,2,3,4-tetrahydroisoquinoline-3-carbaldehyde 
• 782500-96-3 [(2'S,3S)-2-(2'-benzyloxy-5'-methylhex-4'-enyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol 
• 782500-95-2 (2'S,3S)-2-(2'-benzyloxy-5'-methylhex-4'-enyl)-3-(tert-butyldimethylsilyloxymethyl)-1,2,3,4-tetrahydroisoquinoline 
• 102125-88-2 2-((S)-2-Benzyloxycarbonyl-1-hydroxy-4-oxo-1,3,4,6,11,11a-hexahydro-2H-pyrazino[1,2-b]isoquinolin-3-ylmethyl)-malonic acid dimethyl ester 
• 102125-84-8 C₂₆H₂₆N₂O₇ 
• 195832-14-5 S-3-hydroxymethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester 

Relevant articles and documents

STEREOCHEMICAL ASPECTS OF PHOTO-SET INDUCED DIRADICAL CYCLIZATION REACTIONS AS A PART OF ISOQUINOLINE ALAKALOID SYNTHETIC STRATEGIES

Studies of the photo-SET induced cyclization reactions of an N-silylbenzyldihydroisoquinolinium salt have uncovered a potentially interesting feature governing stereoselectivities of diradical cyclization reactions.

(η5-Pentamethylcyclopentadienyl)iridium Complex Catalyzed Imine Reductions Utilizing the Biomimetic 1,4-NAD(P)H Cofactor and N-Benzyl-1,4-dihydronicotinamide as the Hydride-Transfer Agent

The interaction between synthetic organometallic complexes and metabolic cofactors has proven to be a newly emerging topic in bioorganometallic chemistry. Thus, the first cationic Cp*Ir-catalyzed (Cp=η5-pentamethylcyclopentadienyl) imine reduction in neutral buffered aqueous medium was examined. The reaction was found to proceed through hydride transfer from NADH as the hydride source at room temperature in air. Cationic Cp*Ir complexes proved to be the most efficient catalysts for this transformation. We also highlighted that the choice of the proton source was essential. The method was subsequently applied to cyclic and noncyclic imines. Eventually, the concept was extended to the reductive alkylation of one amine.

MODULATORS OF REV-ERB

The subject matter herein concerns the identification and development of potent synthetic REV-ERB ligands, such as in vivo agonists and antagonists. These compounds allow for characterization of the effects of modulation of this receptor in vivo specifically on circadian behavior and metabolism, and have suitable characteristics for development of medicinal compounds useful for treatment of malconditions such as diabetes, obesity, atherosclerosis, dyslipidemia, a circadian rhythm disorder, coronary artery disease, bipolar disorder, depression, cancer, a sleep disorder, an anxiety disorder, an addiction disorder, a bone-related disorder such osteoporosis, a skeletal muscle disease, e.g., with compromised exercise capacity, or an autoimmune disorder such as psoriasis, multiple sclerosis, inflammatory bowel disease, and others.