6301-18-4

Usage

InChI:InChI=1/C15H15NO2/c1-2-18-15(17)16-14-11-7-6-10-13(14)12-8-4-3-5-9-12/h3-11H,2H2,1H3,(H,16,17)

Upstream product

• 90-41-5 2-phenylaniline 
• 541-41-3 chloroformic acid ethyl ester 
• 64-17-5 ethanol 
• 947-84-2 2-Biphenylcarboxylic acid 
• 591-50-4 iodobenzene 
• 101-99-5 N-carboethoxyaniline 
• 98-80-6 phenylboronic acid 

Downstream Products

• 1015-89-0 6(5H)-phenanthridinone 
• 14925-09-8 2-(N-methylamino)-1,1'-biphenyl 
• 90-41-5 2-phenylaniline 

Relevant academic research and scientific papers

Rhodium(III)-catalyzed ortho-arylation of anilides with aryl halides

An efficient o-arylation of pivalamides by aryl iodides via rhodium(III)-catalyzed C-H activation is demonstrated for the first time. Further, the biaryl products can be converted effectively into biologically active phenanthridine and phenanthridinone derivative.

Aniline carbamates: A versatile and removable motif for palladium-catalyzed directed c-h activation

The aniline carbamate is introduced as a new removable directing group for C-H activation. Its versatility and ability as a directing group are demonstrated by its use in the ortho-arylation of a wide variety of aniline derivatives under palladium(II) catalysis, with symmetric diaryliodonium salts as aryl donors. The reaction differs from previously reported arylations in its selectivity and its mechanism, as elucidated by kinetic and isotopic experiments. The directing group can also be easily removed under a variety of conditions.

A modular flow reactor for performing Curtius rearrangements as a continuous flow process

The use of a mesofluidic flow reactor is described for performing Curtius rearrangement reactions of carboxylic acids in the presence of diphenylphosphoryl azide and trapping of the intermediate isocyanates with various nucleophiles. The Royal Society of Chemistry 2008.

Novel orally active, dibenzazepinone-based γ-secretase inhibitors

Structural modifications of the γ-secretase inhibitor, LY411575, led to a malonamide analogue (S),(S)-1 with potent inhibitory activity in vitro, but disappointing activity in a mouse model of Alzheimer's disease. Identification and replacement of a metab

Novel phosphinine compounds and metal complexes thereof

Phosphinines of formula (I) can be combined with metal salts to prepare hydroformylation catalysts. The phosphinine complexes have two phosphorus centers that may be substituted with a variety of hetero atoms or alkyl substituents to modify the ligand characteristics of the phosphinine. Phosphinine metal complexes are employed under normal hydroformylation reaction conditions. The preparatory routes to the phosphinine ligands of formula (I) allow for their convenient synthesis.