63020-20-2

Usage

Properties

1. Organic compound
2. Belongs to the class of carbazoles
3. Yellow-colored solid
4. Soluble in organic solvents

Specific content

1. Used as a reactant in the synthesis of dyes and pharmaceutical drugs
2. Employed in the development of OLEDs as a hole transport material
3. Studied for potential applications in anti-tumor and anticancer therapies
4. Investigated for potential use as a fluorescence probe in analytical chemistry and biochemistry studies

InChI:InChI=1/C14H12N2O/c1-9(17)15-10-6-7-12-11-4-2-3-5-13(11)16-14(12)8-10/h2-8,16H,1H3,(H,15,17)

Upstream product

• 4539-51-9 2-aminocarbazole 
• 75-36-5 acetyl chloride 
• 870703-52-9 9H-carbazol-2-yl trifluoromethanesulfonate 
• 86-79-3 2-hydroxycarbazole 
• 101251-09-6 (4-acetylaminophenyl)boronic acid 
• 615-43-0 2-iodophenylamine 
• 3366-62-9 N-(2'-amino-biphenyl-4-yl)-acetamide 
• 31433-69-9 N-(2'-iodo-biphenyl-4-yl)-acetamide 
• 14191-22-1 2-nitrocarbazole 
• 77229-04-0 2,9-diacetylcarbazole oxime acetic ester 
• 77229-03-9 2-acetylcarbazole oxime acetic ester 
• 77229-02-8 2,9-diacetylcarbazole oxime 
• 23592-73-6 1-(2-acetylcarbazol-9-yl)ethanone 
• 23592-74-7 2-acetylcarbazole 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING DERIVATIVES OF CARBAZOLE

This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from one or more sources of CD34+ cells. Sources of CDS 4+ cells include bone marrow, cord blood, mobilized peripheral blood, and non-mobilized peripheral blood. Also provided herein are compounds of Formula I which are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.

Nitrogen-Iodine Exchange of Diaryliodonium Salts: Access to Acridine and Carbazole

A nitrogen-iodine exchange protocol of diaryliodonium salts with sodium azide salt is developed for general construction of significant functional acridines and carbazoles, in which introduction of nitrogen at a late stage was successfully established avoiding heteroatom incompatibility. Inorganic sodium azide served as the sole nitrogen atom source in this transformation. The diversiform functional acridines and carbazoles were comprehensively achieved through annulated diaryliodonium salts, respectively. Notably, Acridine orange (a fluorescent indicator for cell lysosomal dye) and Carprofen (a nonsteroidal anti-inflammatory drug) were efficiently established through this protocol.

Carbazole compound, and synthesis method and application of compound

The invention discloses a carbazole compound represented by a formula (2) and a synthesis method of the compound. A high-iodine salt is taken as a reaction raw material, and under the action of an inorganic nitrogen reagent, an additive, a base and a metal catalyst, a reaction is carried out in a solvent under a condition of 80-150 DEG C to obtain various carbazole compounds. According to the method provided by the invention, nitrogen atoms are introduced in a later period, so that the non-compatibility of nitrogen heterocyclic rings to the reaction conditions such as the metal catalyst and the like in an early reaction period is avoided. In addition, two aryl groups in the high-iodine salt are fully utilized, so that the atomic economic efficiency of the method provided by the present invention is fully exhibited. The carbazole compound prepared by the method provided by the invention can be further applied to the synthesis of non-steroidal anti-inflammatory drug carprofen.

Catalytic C-H Functionalization Driven by CO as a Stoichiometric Reductant: Application to Carbazole Synthesis

(Equation presented) A palladium-catalyzed regioselective C-H bond functionalization driven by CO as the stoichiometric reductant is described. Nitrogen heterocycles, e.g., carbazoles, are accessible in good to excellent yields with use of palladium acetate and 70 psig of carbon monoxide at 140°C.