630384-19-9

Basic information

• Product Name: Carbamic acid, [1-(4-iodophenyl)cyclopropyl]-, 1,1-dimethylethyl ester
• CAS NO: 630384-19-9
• Molecular Formula: C14H18INO2
• Molecular Weight: 359.207
• Mol File: 630384-19-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [1-(4-iodophenyl)cyclopropyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [1-(4-iodophenyl)cyclopropyl]-, 1,1-dimethylethyl ester(630384-19-9)
• EPA Substance Registry System: Carbamic acid, [1-(4-iodophenyl)cyclopropyl]-, 1,1-dimethylethyl ester(630384-19-9)

Safety Data

• Hazardous Substances Data: 630384-19-9(Hazardous Substances Data)

Upstream product

• 124276-89-7 1-(4-iodophenyl)cyclopropane-1-carboxylic acid 
• 4129-17-3 diphenylphosphoranyl azide 
• 75-65-0 tert-butyl alcohol 
• 360773-84-8 tert-butyl [1-(4-bromophenyl)-cyclopropyl]-carbamate 

Downstream Products

• 858677-79-9 3-[4-(1-tert-butoxycarbonyl-amino-cyclopropyl)-phenyl]-propynoic acid (4'-chloro-biphenyl-4-yl)-amide 
• 630384-24-6 [1-(4-iodo-phenyl)-cyclopropyl]-methyl-carbamic acid tert-butyl ester 
• 630384-20-2 [1-(4-Iodophenyl)cyclopropyl]amine 

Relevant articles and documents

Discovery of Novel Inhibitors of LpxC Displaying Potent in Vitro Activity against Gram-Negative Bacteria

UDP-3-O-((R)-3-hydroxymyristoyl)-N-glucosamine deacetylase (LpxC) is as an attractive target for the discovery and development of novel antibacterial drugs to address the critical medical need created by multidrug resistant Gram-negative bacteria. By using a scaffold hopping approach on a known family of methylsulfone hydroxamate LpxC inhibitors, several hit series eliciting potent antibacterial activities against Enterobacteriaceae and Pseudomonas aeruginosa were identified. Subsequent hit-to-lead optimization, using cocrystal structures of inhibitors bound to Pseudomonas aeruginosa LpxC as guides, resulted in the discovery of multiple chemical series based on (i) isoindolin-1-ones, (ii) 4,5-dihydro-6H-thieno[2,3-c]pyrrol-6-ones, and (iii) 1,2-dihydro-3H-pyrrolo[1,2-c]imidazole-3-ones. Synthetic methods, antibacterial activities and relative binding affinities, as well as physicochemical properties that allowed compound prioritization are presented. Finally, in vivo properties of lead molecules which belong to the most promising pyrrolo-imidazolone series, such as 18d, are discussed.

Highly efficacious factor Xa inhibitors containing α-substituted phenylcycloalkyl P4 moieties

We previously disclosed a series of highly potent FXa inhibitors bearing α-substituted (CH2NR1R2) phenylcyclopropyl P4 moieties in the pyrazolodihydropyridone core system. Herein, we describe our continuous SAR efforts in

1,1-DISUBSTITUTED CYCLOALKYL DERIVATIVES AS FACTOR XA INHIBITORS

The present application describes 1,1-disubstituted cycloalkyl compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.