630385-38-5Relevant academic research and scientific papers
Orally bioavailable factor Xa inhibitors containing alpha-substituted gem-dimethyl P4 moieties
Orwat, Michael J.,Qiao, Jennifer X.,He, Kan,Rendina, Alan R.,Luettgen, Joseph M.,Rossi, Karen A.,Xin, Baomin,Knabb, Robert M.,Wexler, Ruth R.,Lam, Patrick Y.S.,Pinto, Donald J.P.
, p. 3341 - 3345 (2014)
In an effort to identify a potential back-up to apixaban (Eliquis), we explored a series of diversified P4 moieties. Several analogs with substituted gem-dimethyl moieties replacing the terminal lactam of apixaban were identified which demonstrated potent
1,1-DISUBSTITUTED CYCLOALKYL DERIVATIVES AS FACTOR XA INHIBITORS
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Page 435, (2010/02/05)
The present application describes 1,1-disubstituted cycloalkyl compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
