630400-05-4

Basic information

• Product Name: 5-cyano-1-ethoxycarbonylmethyl-8-methyl-1-propyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indole-7-carboxylic acid benzyl ester
• Synonyms: 5-cyano-1-ethoxycarbonylmethyl-8-methyl-1-propyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indole-7-carboxylic acid benzyl ester
• CAS NO: 630400-05-4
• Molecular Weight: 474.557
• Mol File: 630400-05-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-cyano-1-ethoxycarbonylmethyl-8-methyl-1-propyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indole-7-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-cyano-1-ethoxycarbonylmethyl-8-methyl-1-propyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indole-7-carboxylic acid benzyl ester(630400-05-4)
• EPA Substance Registry System: 5-cyano-1-ethoxycarbonylmethyl-8-methyl-1-propyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indole-7-carboxylic acid benzyl ester(630400-05-4)

Safety Data

• Hazardous Substances Data: 630400-05-4(Hazardous Substances Data)

Upstream product

• 630400-04-3 5-bromo-1-ethoxycarbonylmethyl-8-methyl-1-propyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indole-7-carboxylic acid benzyl ester 
• 544-92-3 copper(I) cyanide 
• 1975-50-4 2-methyl-3-nitrobenzic acid 
• 788820-59-7 C₁₅H₁₅BrN₂O₂ 
• 630400-01-0 3-Amino-5-bromo-2-methylbenzoic acid benzyl ester 
• 630400-00-9 5-Bromo-2-methyl-3-nitrobenzoic acid benzyl ester 
• 107650-20-4 5-bromo-2-methyl-3-nitro-benzoic acid 
• 630400-03-2 4-bromo-3-(2-hydroxy-ethyl)-7-methyl-1H-indole-6-carboxylic acid benzyl ester 
• 3249-68-1 ethyl butyroyl acetate 

Downstream Products

• 1312782-04-9 C₂₆H₂₇N₃O₄ 

Relevant articles and documents

The discovery and structure-activity relationships of pyrano[3,4-b]indole- based inhibitors of hepatitis C virus NS5B polymerase

We describe the structure-activity relationship of the C7-position of pyrano[3,4-b]indole-based inhibitors of HCV NS5B polymerase. Further exploration of the allosteric binding site led to the discovery of the significantly more potent compounds 13 and 14

METHOD FOR THE USE OF PYRANOINDOLE DERIVATIVES TO TREAT INFECTION WITH HEPATITIS C VIRUS

The invention is directed to methods of treating, preventing, or inhibiting a Hepatitis C viral infection in a mammal comprising containing the mammal with an effective amount of a compound of the formula: Wherein substitutions at R1, R2, R3-R12, and Y are set forth in the specification.